ReviewBiochemistry2011
Investigating endogenous peptides and peptidases using peptidomics.
Review in Biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Single-Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hyperpolarization Modulation of the T-Type hCaAngewandte Chemie (International ed. in English) · 2025Article
- MotifQuest: An Automated Pipeline for Motif Database Creation to Improve Peptidomics Database Searching Programs.Journal of the American Society for Mass Spectrometry · 2024Article
- Revealing Natural Intracellular Peptides in Gills of SeahorseBiomolecules · 2023Article
- Aquaglyceroporin Modulators as Emergent Pharmacological Molecules for Human Diseases.Frontiers in molecular biosciences · 2022Review
- Protein Hydrolysis by Subcritical Water: A New Perspective on Obtaining Bioactive Peptides.Molecules (Basel, Switzerland) · 2021Review
- Exploiting Knowledge on Structure-Activity Relationships for Designing Peptidomimetics of Endogenous Peptides.Biomedicines · 2021Review
- Peptidomics and Capillary Electrophoresis.Advances in experimental medicine and biology · 2021Article
- Peptides to combat viral infectious diseases.Peptides · 2020Review
- Characterization of the Ovarian Tumor Peptidome.Vitamins and hormones · 2018Article
- Common and phylogenetically widespread coding for peptides by bacterial small RNAs.BMC genomics · 2017Article
- A novel approach for characterizing variations in serum peptides in rheumatic heart disease.The Indian journal of medical research · 2017Article
- An Optimized Informatics Pipeline for Mass Spectrometry-Based Peptidomics.Journal of the American Society for Mass Spectrometry · 2015Article
- Quantitative peptidomics study reveals that a wound-induced peptide from PR-1 regulates immune signaling in tomato.The Plant cell · 2014Article
- Biomarkers in Alzheimer's disease analysis by mass spectrometry-based proteomics.International journal of molecular sciences · 2014Review
- Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Selective, bead-based global peptide capture using a bifunctional cross-linker.Analytical chemistry · 2013Article
- Liquid chromatography/mass spectrometry methods for measuring dipeptide abundance in non-small-cell lung cancer.Rapid communications in mass spectrometry : RCM · 2013Article
- Extracellular identification of a processed type II ComR/ComS pheromone of Streptococcus mutans.Journal of bacteriology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Rather than simply being protein degradation products, peptides have proven to be important bioactive molecules. Bioactive peptides act as hormones, neurotransmitters, and antimicrobial agents in vivo. The dysregulation of bioactive peptide signaling is also known to be involved in disease, and targeting peptide hormone pathways has been a successful strategy in the development of novel therapeutics. The importance of bioactive peptides in biology has spurred research to elucidate the function and regulation of these molecules. Classical methods for peptide analysis have relied on targeted immunoassays, but certain scientific questions necessitated a broader and more detailed view of the peptidome--all the peptides in a cell, tissue, or organism. In this review we discuss how peptidomics has emerged to fill this need through the application of advanced liquid chromatography--tandem mass spectrometry (LC-MS/MS) methods that provide unique insights into peptide activity and regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.