ArticleEMBO molecular medicine2011
Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function.
Article in EMBO molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Review
- Inducible general knockout of Runx3 profoundly reduces pulmonary cytotoxic CD8Frontiers in immunology · 2022Article
- DYNLRB1 is essential for dynein mediated transport and neuronal survival.Neurobiology of disease · 2020Article
- Elevated expression of RUNX3 co-expressing with EZH2 in esophageal cancer patients from India.Cancer cell international · 2020Article
- Runx3 prevents spontaneous colitis by directing the differentiation of anti-inflammatory mononuclear phagocytes.PloS one · 2020Article
- RUNX family: Oncogenes or tumor suppressors (Review).Oncology reports · 2019Review
- Genetic Mutations and Epigenetic Modifications: Driving Cancer and Informing Precision Medicine.BioMed research international · 2017Review
- Truncated forms of RUNX3 Unlike Full Length Protein Alter Cell Proliferation in a TGF-β Context Dependent Manner.Iranian journal of pharmaceutical research : IJPR · 2017Article
- An ensemble of regulatory elements controls Runx3 spatiotemporal expression in subsets of dorsal root ganglia proprioceptive neurons.Genes & development · 2016Article
- Article
- Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer.Oncogene · 2015Article
- Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.Molecular and cellular biology · 2014Article
- Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host.Nature reviews. Cancer · 2013Review
- Genomic insights into cancer-associated aberrant CpG island hypermethylation.Briefings in functional genomics · 2013Review
- Antitumor activity of cell-permeable RUNX3 protein in gastric cancer cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Transcriptional reprogramming of CD11b+Esam(hi) dendritic cell identity and function by loss of Runx3.PloS one · 2013Article
- Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns.Genome biology · 2012Article
- RUNX3 is expressed in the epithelium of the gastrointestinal tract.EMBO molecular medicine · 2012Article
- Article
- RUNX3 as a Potential Predictor of Metastasis in Human Pancreatic Cancer.In vivo (Athens, Greece)Article
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9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The Runx3 transcription factor regulates cell fate decisions during embryonic development and in adults. It was previously reported that Runx3 is strongly expressed in embryonic and adult gastrointestinal tract (GIT) epithelium (Ep) and that its loss causes gastric cancer. More than 280 publications have based their research on these findings and concluded that Runx3 is indeed a tumour suppressor (TS). In stark contrast, using various measures, we found that Runx3 expression is undetectable in GIT Ep. Employing a variety of biochemical and genetic techniques, including analysis of Runx3-GFP and R26LacZ/Runx3(Cre) or R26tdTomato/Runx3(Cre) reporter strains, we readily detected Runx3 in GIT-embedded leukocytes, dorsal root ganglia, skeletal elements and hair follicles. However, none of these approaches revealed detectable Runx3 levels in GIT Ep. Moreover, our analysis of the original Runx3(LacZ/LacZ) mice used in the previously reported study failed to reproduce the GIT expression of Runx3. The lack of evidence for Runx3 expression in normal GIT Ep creates a serious challenge to the published data and undermines the notion that Runx3 is a TS involved in cancer pathogenesis.
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