ArticleCardiovascular drugs and therapy2011
Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts.
Article in Cardiovascular drugs and therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Two weeks of remote ischemic conditioning improves brachial artery flow mediated dilation in chronic stroke survivors.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- A comprehensive review on current understanding of bradykinin in COVID-19 and inflammatory diseases.Molecular biology reports · 2022Review
- Opportunities and challenges of pain-related myocardial ischemia-reperfusion injury.Frontiers in physiology · 2022Review
- Remote Conditioning by Rhythmic Compression of Limbs Ameliorated Myocardial Infarction by Downregulation of InflammationFrontiers in cardiovascular medicine · 2021Article
- Bradykinin and noradrenaline preconditioning influences level of antioxidant enzymes SOD, CuZn-SOD, Mn-SOD and catalase in the white matter of spinal cord in rabbits after ischemia/reperfusion.European journal of histochemistry : EJH · 2019Article
- Cardioprotection via the skin: nociceptor-induced conditioning against cardiac MI in the NIC of time.American journal of physiology. Heart and circulatory physiology · 2019Article
- Remote ischemic conditioning in ST-segment elevation myocardial infarction - an update.Conditioning medicine · 2018Article
- Responses of Endothelial Cells Towards Ischemic Conditioning Following Acute Myocardial Infarction.Conditioning medicine · 2018Article
- Limb Remote Ischemic Conditioning: Mechanisms, Anesthetics, and the Potential for Expanding Therapeutic Options.Frontiers in neurology · 2018Review
- Transient receptor potential vanilloid 1 inhibitors block laparotomy- and opioid-induced infarct size reduction in rats.British journal of pharmacology · 2017Article
- Remote Ischemic Conditioning by Effluent Collected from a Novel Isolated Hindlimb Model Reduces Infarct Size in an Isolated Heart Model.Korean circulation journal · 2017Article
- Effects of Remote Ischemic Preconditioning on Heme Oxygenase-1 Expression and Cutaneous Wound Repair.International journal of molecular sciences · 2017Article
- Cardioprotection by remote ischemic conditioning and its signal transduction.Pflugers Archiv : European journal of physiology · 2017Review
- Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction.Journal of visualized experiments : JoVE · 2016Article
- Remote ischaemic conditioning in the context of type 2 diabetes and neuropathy: the case for repeat application as a novel therapy for lower extremity ulceration.Cardiovascular diabetology · 2016Review
- Preconditioning boosts regenerative programmes in the adult zebrafish heart.Open biology · 2016Article
- Remote ischaemic preconditioning: closer to the mechanism?F1000Research · 2016Review
- Remote ischaemic conditioning-a new paradigm of self-protection in the brain.Nature reviews. Neurology · 2015Review
- Invasive surgery reduces infarct size and preserves cardiac function in a porcine model of myocardial infarction.Journal of cellular and molecular medicine · 2015Article
- Cardioprotection by remote ischemic conditioning: Mechanisms and clinical evidences.World journal of cardiology · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveRecently, a novel observation was made in which nonischemic trauma at a site remote from the heart produced by a transverse abdominal incision resulted in a marked reduction of infarct size (IS) in the mouse heart via activation of sensory nerve fibers in the skin and subsequent activation of bradykinin 2 receptors (BK2R). This phenomenon was termed remote preconditioning of trauma (RPCT). Since RPCT may have potential clinical implications we attempted to confirm these findings in a large animal model, the dog. The epoxyeicosatrienoic acids (EETs) have also recently been shown to be antinociceptive and have been shown to mimic ischemic preconditioning (IPC) and postconditioning (POC) in dogs, therefore, we tested the role of the EETs in RPCT.
methodsAnesthetized adult mongrel dogs of either sex were subjected to 60 min of left anterior descending (LAD) coronary artery occlusion followed by 3 h of reperfusion. In all groups except the controls (no slit), a transverse slit (9 cm) was applied to the abdominal wall of the dog being careful to only slit the skin. Subsequently, 15 min after the slit the heart was subjected to the ischemia/reperfusion protocol.
resultsIn the control dogs, the IS as a percent of the area at risk (AAR) was 22.5 ± 2.4%, whereas in the dogs subjected to the slit alone the IS/AAR was reduced to 9.2 ± 1.2% (*P < 0.01). The BR2R blocker, HOE 140 (50 ug/kg, iv) given 10 min prior to the slit, completely abolished the protective effects of RCPT as did pretreatment with 14,15-EEZE, a putative EET receptor blocker or pretreatment with the selective EET synthesis inhibitor, MSPPOH.
conclusionsThese results suggest that BK and the EETs share cardioprotective properties in a large animal model of RPCT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.