Evidence map›Paper›PMID 21786203›Full record

ReviewCurrent topics in behavioral neurosciences2013

Synaptic effects induced by alcohol.

David M Lovinger, Marisa Roberto

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in behavioral neurosciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
7.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 145 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Richardson's law and the origins of alcohol research.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Synaptic Effects Induced by Alcohol.Current topics in behavioral neurosciences · 2025
    Review
  12. Toluene Toxicity in the Brain: From Cellular Targets to Molecular Mechanisms.Annual review of pharmacology and toxicology · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

David M LovingerLaboratory for Integrative Neuroscience, NIAAA, 5625 Fishers Lane, Room TS-13A, Rockville, MD 20852, USA. lovindav@mail.nih.gov
Marisa Roberto
National Institute on Alcohol Abuse and Alcoholism · USScripps Research Institute · US

Funding

Synaptic Transmission: Modulation, Plasticity And Effects Of Drugs Of AbuseZIAAA000407 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOVINGER, DAVID M · 2009 to 2025
$29.6M
Synaptic Transmission: Modulation, Plasticity And Effects Of Drugs Of AbuseZ01AA000407 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOVINGER, DAVID M · 2002 to 2008
$3.6M
Synaptic and peptidergic neuroadaptations associated with alcohol dependenceR01AA016985 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2008 to 2012
$2.1M
Intramural NIH HHS Z01 AA000407NIAAA NIH HHS R01 AA016985
6 · The paper itself

Abstract

Ethanol (EtOH) has effects on numerous cellular molecular targets, and alterations in synaptic function are prominent among these effects. Acute exposure to EtOH activates or inhibits the function of proteins involved in synaptic transmission, while chronic exposure often produces opposing and/or compensatory/homeostatic effects on the expression, localization, and function of these proteins. Interactions between different neurotransmitters (e.g., neuropeptide effects on release of small molecule transmitters) can also influence both acute and chronic EtOH actions. Studies in intact animals indicate that the proteins affected by EtOH also play roles in the neural actions of the drug, including acute intoxication, tolerance, dependence, and the seeking and drinking of EtOH. This chapter reviews the literature describing these acute and chronic synaptic effects of EtOH and their relevance for synaptic transmission, plasticity, and behavior.

Indexed as

AnimalsCentral Nervous System DepressantsCorticotropin-Releasing HormoneEthanolIon ChannelsNeuronal PlasticityNeuropeptidesNeurotransmitter AgentsPresynaptic TerminalsReceptors, G-Protein-CoupledSynapsesCentral Nervous System DepressantsCorticotropin-Releasing HormoneEthanolIon ChannelsNeuropeptidesNeurotransmitter AgentsReceptors, G-Protein-Coupled

Identifiers

PMID21786203
PMCPMC4791588
OpenAlexW150093770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.