Evidence map›Paper›PMID 21786074›Full record

ReviewJournal of neurovirology2011

MicroRNA: implications in HIV, a brief overview.

Sudheesh Pilakka-Kanthikeel, Zainulabedin M Saiyed, Jessica Napuri, Madhavan P N Nair

Abstract readReview
In one paragraph

Review in Journal of neurovirology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Sudheesh Pilakka-KanthikeelDepartment of Immunology, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA.
Zainulabedin M Saiyed
Jessica Napuri
Madhavan P N Nair
Florida International University · US

Funding

Polydrug Nanocarrier to Treat Opiate Addiction and HIV DiseaseR01DA027049 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2009 to 2014
$3.1M
Immunopathogenesis of HIV-1 Infection: Role of MethamphetamineR01DA021537 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2006 to 2010
$2.0M
Role of Cocaine in Neuro-AIDS by HIV 1B and C CladesR37DA025576 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2008 to 2012
$1.7M
Mechanisms of Neuro-AIDS by HIV 1B and C CladesR01MH085259 · NIMH · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2010 to 2014
$1.7M
NIDA NIH HHS R01 DA021537NIDA NIH HHS R01-DA021537NIDA NIH HHS R01-DA025576NIDA NIH HHS R01 DA027049NIDA NIH HHS R01-DA027049NIDA NIH HHS R37 DA025576NIMH NIH HHS 1R01MH085259NIMH NIH HHS R01 MH085259
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are 20-22 nucleotide length noncoding RNA molecules that represent key regulators of many normal cellular functions. miRNAs undergo two processing steps which transform a long primary transcript into the mature miRNA. Available literatures demonstrate the association between alterations in the expression of miRNAs and the progression of numerous human disorders. Even though significant advances have been made, many fundamental questions about their expression and function still remain unanswered. Identifying factors that block the negative action of drugs of abuse on the miRNAs could help in identifying new therapeutic strategies. In this review, we briefly discuss the importance of miRNAs on HIV, strategies used by virus to avoid the cells' antiviral miRNA defenses, and how HIV might control and regulate host cell genes by encoding viral miRNAs.

Indexed as

AnimalsGene SilencingHIVHIV InfectionsHumansIllicit DrugsMicroRNAsRNA, ViralVirus LatencyIllicit DrugsMicroRNAsRNA, Viral

Identifiers

PMID21786074
PMCPMC4476028
OpenAlexW2012558709

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.