ArticleEuropean journal of epidemiology2011
Categories of glucose tolerance and continuous glycemic measures and mortality.
Article in European journal of epidemiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Prediabetes and the risk of cancer: a meta-analysis.Diabetologia · 2014Pooled it
- Trial
- PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-Cohort.Cardiovascular diabetology · 2014Trial
- Prediabetes and Risk of All-Cause and Cause-Specific Mortality: A Prospective Study of 114 062 Adults in Mexico City.The Journal of clinical endocrinology and metabolism · 2025Article
- Conceptual Overview of Prevalence of Prediabetes.Current diabetes reviews · 2025Review
- Combined effects of maximal oxygen uptake and glucose status on mortality: The Prospective KIHD cohort study.Scandinavian journal of medicine & science in sports · 2022Article
- Different Curve Shapes of Fasting Glucose and Various Obesity-Related Indices by Diabetes and Sex.International journal of environmental research and public health · 2021Article
- Prediabetes, Diabetes, and the Risk of All-Cause and Cause-Specific Mortality in a Japanese Working Population: Japan Epidemiology Collaboration on Occupational Health Study.Diabetes care · 2021Article
- Natural history of prediabetes in older adults from a population-based longitudinal study.Journal of internal medicine · 2019Observational
- Prevalence, incidence and mortality of diabetes mellitus in adults in Germany - A review in the framework of the Diabetes Surveillance.Journal of health monitoring · 2017Article
- All-cause mortality in adults with and without type 2 diabetes: findings from the national health monitoring in Germany.BMJ open diabetes research & care · 2017Article
- Perceived risk of diabetes seriously underestimates actual diabetes risk: The KORA FF4 study.PloS one · 2017Article
- Associations Between the Serum Metabolome and All-Cause Mortality Among African Americans in the Atherosclerosis Risk in Communities (ARIC) Study.American journal of epidemiology · 2016Article
- Type 2 Diabetes in the Elderly: Challenges in a Unique Patient Population.Journal of geriatric medicine and gerontology · 2016Article
- Prevalence, incidence and concomitant co-morbidities of type 2 diabetes mellitus in South Western Germany--a retrospective cohort and case control study in claims data of a large statutory health insurance.BMC public health · 2015Article
- Impact of glucose level on morbidity and mortality in elderly with diabetes and pre-diabetes.World journal of diabetes · 2015Review
- Prediabetes and associated disorders.Endocrine · 2015Review
- The risk of total mortality and cardiovascular mortality associated with impaired glucose regulation in Tayside, Scotland, UK: a record-linkage study in 214 094 people.BMJ open diabetes research & care · 2015Article
- Article
- Regional differences of undiagnosed type 2 diabetes and prediabetes prevalence are not explained by known risk factors.PloS one · 2014Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the association of undiagnosed diabetes, previously known diabetes and prediabetes (WHO 1999 classification) with all-cause and cause-specific mortality in an older German population. Previous study results for mortality in patients with very low levels of HbA1c, fasting plasma glucose (FPG), and 2-h plasma glucose (2hPG) are still inconclusive. Thus we have extended the analyses to continuous measures of glycemia. A total of 1,466 subjects aged 55-74 years from the population-based KORA survey S4 (conducted from 1999 to 2001) were included in our observational mortality study (152 subjects with previously known diabetes, and 1,314 further subjects who underwent oral glucose tolerance tests). Mortality was followed up for a maximum of 10.0 years (median follow-up 8.8 years). A total of 180 (12.3%) of the 1,466 subjects have died during the follow-up period. The age- and sex-adjusted hazard ratios for all-cause mortality were 2.6 (95%CI, 1.7-3.8) for known diabetes, 2.8 (95%CI, 1.7-4.4) for undiagnosed diabetes, and 1.1 (95%CI, 0.8-1.7) for prediabetes [reference: normal glucose tolerance (NGT)]. After multivariable adjustment, undiagnosed diabetes was associated with 3.0-fold increased cancer mortality, 1.1-fold increased cardiovascular mortality, and 4.7-fold increased non-cancer, non-cardiovascular mortality compared with NGT. For HbA1c, FPG, and 2hPG, J-shaped associations with all-cause mortality were observed. Undiagnosed diabetes is associated with increased all-cause, cancer, and non-cancer non-cardiovascular mortality, but not with cardiovascular mortality in this older population. All-cause mortality in undiagnosed diabetes is similar to that in previously known diabetes but much higher than mortality in prediabetes and NGT.
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