ReviewStem cell reviews and reports2012
Hidden treasures in stem cells of indeterminately growing bilaterian invertebrates.
Review in Stem cell reviews and reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Eupentacta fraudatrix: the first chromosome-level holothurian genome with extraordinarily high heterozygosity.Scientific data · 2026Article
- Prolonged starvation deepens quiescence in Vasa2/Piwi1-expressing cells of a sea anemone.PLoS biology · 2025Article
- Widespread presence of bone marrow-like hematopoietic stem cell niche in invertebrate skeletons.Science advances · 2025Article
- Article
- The cellular basis of feeding-dependent body size plasticity in sea anemones.Development (Cambridge, England) · 2024Article
- Experimental Infection Models and Their Usefulness for White Spot Syndrome Virus (WSSV) Research in Shrimp.Viruses · 2024Review
- Annelids as models of germ cell and gonad regeneration.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Review
- Echinoderm radial glia in adult cell renewal, indeterminate growth, and regeneration.Frontiers in neural circuits · 2023Review
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Expression ofGenes · 2021Article
- Review
- Stem Cells and Innate Immunity in Aquatic Invertebrates: Bridging Two Seemingly Disparate Disciplines for New Discoveries in Biology.Frontiers in immunology · 2021Review
- Investigating the genetic and epigenetic basis of big biological questions with the parthenogenetic marbled crayfish: A review and perspectives.Journal of biosciences · 2018Review
- Article
- Impaired telomerase activity hinders proliferation and in vitro transformation of Penaeus monodon lymphoid cells.Cytotechnology · 2016Article
- Cancer across the tree of life: cooperation and cheating in multicellularity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Stochastic developmental variation, an epigenetic source of phenotypic diversity with far-reaching biological consequences.Journal of biosciences · 2015Review
- Cellular and molecular mechanisms of negligible senescence: insight from the sea urchin.Invertebrate reproduction & development · 2015Article
- Tissue regeneration and biomineralization in sea urchins: role of Notch signaling and presence of stem cell markers.PloS one · 2015Article
- Establishment of shrimp cell lines: perception and orientation.Indian journal of virology : an official organ of Indian Virological Society · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indeterminate growth, the life-long growth without fixed limits, is typical of some evolutionarily very successful aquatic invertebrate groups such as the decapod crustaceans, bivalve molluscs and echinoderms. These animals enlarge their organs also in the adult life period and can regenerate lost appendages and organs, which is in sharp contrast to mammals and most insects. Interestingly, decapods, bivalves and echinoderms develop only rarely neoplastic and age-related diseases, although some species reach ages exceeding 100 years. Their stem cell systems must have co-evolved with these successful life histories suggesting possession of unknown and beneficial features that might open up new vistas in stem cell biology. Research of the last decade has identified several adult stem cell systems in these groups and also some mature cell types that are capable to dedifferentiate into multipotent progenitor cells. Investigation of stem and progenitor cells in indeterminately growing bilaterian invertebrates is assumed beneficial for basic stem cell biology, aquaculture, biotechnology and perhaps medicine. The biggest treasure that could be recovered in these animal taxa concerns maintenance of stem cell niches and fidelity of stem cell division for decades without undesirable side effects such as tumour formation. Uncovering of the underlying molecular and regulatory mechanisms might evoke new ideas for the development of anti-ageing and anti-cancer interventions in humans.
Indexed as
Identifiers
21785941What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.