ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2011
A blunted heart rate response to regadenoson is an independent prognostic indicator in patients undergoing myocardial perfusion imaging.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01842035 (Heart Rate Response to Regadenoson and Sudden Cardiac Death), which is not on this map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Heart Rate Response to Regadenoson and Sudden Cardiac Death
Who cites it
59 citing papers in PubMed.
- Prognostic value of heart rate response during regadenoson stress myocardial perfusion imaging in patients with end stage renal disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Trial
- The heart rate response to adenosine: a simple predictor of adverse cardiac outcomes in asymptomatic patients with type 2 diabetes.International journal of cardiology · 2013Trial
- Safety, feasibility, and hemodynamic response of regadenoson for stress perfusion CMR.The international journal of cardiovascular imaging · 2023Article
- Improved Performance of PET Myocardial Perfusion Imaging Compared to SPECT in the Evaluation of Suspected CAD.Current cardiology reports · 2023Review
- Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2022: single photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Prognostic value of heart rate reserve in patients with suspected coronary artery disease undergoing stress myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Prognostic value of absent left ventricular ejection fraction reserve with regadenoson SPECT MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- The association between heart rate reserve and impaired coronary flow velocity reserve: a study based on adenosine stress echocardiography.The international journal of cardiovascular imaging · 2022Review
- The evolution of the prognostic value of regadenoson SPECT myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Relationship between heart rate response and cardiac innervation in patients with suspected or known coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Stress testing and myocardial perfusion imaging for patients after recovery from severe COVID-19 infection requiring hospitalization: A single-center experience.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Prevalence of abnormal SPECT myocardial perfusion imaging during the COVID-19 pandemic.European journal of nuclear medicine and molecular imaging · 2021Article
- Deriving myocardial blood flow reserve from perfusion datasets: Dream or reality?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Microvascular dysfunction and sympathetic hyperactivity in women with supra-normal left ventricular ejection fraction (snLVEF).European journal of nuclear medicine and molecular imaging · 2020Article
- Stress cardiomyopathy associated with vasodilator stress testing.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2019: Single-photon emission computed tomography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Heart rate and 123I-MIBG in heart failure with preserved ejection fraction: More variability and slower washout-A secret recipe for better survival.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Increased long-term mortality in women with high left ventricular ejection fraction: data from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) long-term registry.European heart journal. Cardiovascular Imaging · 2020Article
- Sex and age differences in the association of heart rate responses to adenosine and myocardial ischemia in patients undergoing myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Gender-related differences in side-effects and hemodynamic response to regadenoson in patients undergoing SPECT myocardial perfusion imaging.European journal of nuclear medicine and molecular imaging · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegadenoson myocardial perfusion imaging (MPI) is a useful method for risk assessment. We hypothesized that the heart rate response (HRR) to regadenoson carries incremental prognostic information to that derived from perfusion pattern and left ventricular (LV) ejection fraction (EF). METHODS AND
resultsThe study population included 1,156 (60 ± 13 years, 46% women, 40% diabetes mellitus, 53% chronic kidney disease) patients. During a follow-up period of 22 ± 5 months, 103 patients died (9%). Independent determinants of the HRR included age, gender, race, diabetes mellitus, coronary revascularization, LVEF, use of insulin and aldosterone antagonists. Decreasing HRR was associated with stepwise increase in mortality (log-rank P < .0001). In a Cox proportional model for mortality that adjusted for age, gender, diabetes mellitus, renal disease, and MPI findings, HRR in the lowest quartile was independently associated with fivefold increase in mortality compared to the highest quartile [HR 5.2, 95% CI 2.3-12.0, P < .0001]. Patients with a normal HRR had a relatively low annualized total mortality despite the presence of risk factors. The addition of HRR to traditional MPI findings had a net reclassification improvement of 15%, P = .02.
conclusionA blunted HRR to regadenoson is an independent predictor of poor outcome, adds incremental value to MPI, and helps in better risk stratification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.