ArticleMolecular imaging and biology2012
Quantification of skeletal blood flow and fluoride metabolism in rats using PET in a pre-clinical stress fracture model.
Article in Molecular imaging and biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Unraveling stress fractures: from cellular and molecular mechanisms to therapeutic approaches.Journal of orthopaedic translation · 2026Review
- Patients with unilateral patellofemoral pain have altered bone turnover in the painful knee compared to the pain-free knee at rest and after acute knee loading.Osteoarthritis and cartilage open · 2025Article
- Metabolic bone imaging and its relationship with biomechanics.Osteoarthritis imaging · 2024Article
- Imaging of joint response to exercise with MRI and PET.Skeletal radiology · 2023Review
- [Osteoarthritis and cartilage · 2022Article
- Similarities Between Disuse and Age-Induced Bone Loss.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Review
- Minimally invasive laser Doppler flowmetry is suitable for serial bone perfusion measurements in mice.Bone reports · 2019Article
- Assessment of acute bone loading in humans using [European journal of nuclear medicine and molecular imaging · 2019Article
- Kinetic [18F]-Fluoride of the Knee in Normal Volunteers.Clinical nuclear medicine · 2019Article
- Design, Synthesis, and In Vitro and In Vivo Evaluation of an (18)F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer.Journal of medicinal chemistry · 2016Article
- Antagonizing the αv β3 integrin inhibits angiogenesis and impairs woven but not lamellar bone formation induced by mechanical loading.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- 18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis.Arthritis research & therapy · 2014Article
- Nitric oxide-mediated vasodilation increases blood flow during the early stages of stress fracture healing.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Skeletal Blood Flow in Bone Repair and Maintenance.Bone research · 2013Review
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeBlood flow is an important factor in bone production and repair, but its role in osteogenesis induced by mechanical loading is unknown. Here, we present techniques for evaluating blood flow and fluoride metabolism in a pre-clinical stress fracture model of osteogenesis in rats. PROCEDURES: Bone formation was induced by forelimb compression in adult rats. (15)O water and (18)F fluoride PET imaging were used to evaluate blood flow and fluoride kinetics 7 days after loading. (15)O water was modeled using a one-compartment, two-parameter model, while a two-compartment, three-parameter model was used to model (18)F fluoride. Input functions were created from the heart, and a stochastic search algorithm was implemented to provide initial parameter values in conjunction with a Levenberg-Marquardt optimization algorithm.
resultsLoaded limbs are shown to have a 26% increase in blood flow rate, 113% increase in fluoride flow rate, 133% increase in fluoride flux, and 13% increase in fluoride incorporation into bone as compared to non-loaded limbs (p < 0.05 for all results).
conclusionsThe results shown here are consistent with previous studies, confirming this technique is suitable for evaluating the vascular response and mineral kinetics of osteogenic mechanical loading.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.