Evidence map›Paper›PMID 21785849›Full record

ArticlePediatric radiology2011

Medication neurotoxicity in children.

Ramesh S Iyer, Apeksha Chaturvedi, Sumit Pruthi, Paritosh C Khanna, Gisele E Ishak

Abstract read
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In one paragraph

Article in Pediatric radiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Posterior Reversible Encephalopathy Syndrome, not so Uncommon in Pediatric Patients with Renal Involvement: A Case Series.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024
    Article
  2. Article
  3. Review
  4. Metronidazole-Induced Cerebellar Toxicity.Neurology international · 2016
    Article
  5. Neurometabolic diseases of childhood.Pediatric radiology · 2015
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ramesh S IyerDepartment of Radiology, Seattle Children's Hospital, Seattle, WA 98105, USA. riyer@uw.edu
Apeksha Chaturvedi
Sumit Pruthi
Paritosh C Khanna
Gisele E Ishak

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medication neurotoxicity may have a variety of imaging manifestations in children. In this pictorial essay, we review the two most common brain injury patterns, posterior reversible encephalopathy syndrome (PRES) and acute toxic leukoencephalopathy (ATL). Proposed etiologies, salient features on neurological imaging, and methods for differentiating these entities and their implications will be discussed. Certain agents do not fall into these two broad patterns but instead characteristically involve central structures. We individually review several medications and their respective neurotoxic appearances including methotrexate, cyclosporine A, tacrolimus, metronidazole and vigabatrin. Diagnosis of medication neurotoxicity may be achieved by the combination of new-onset neurological deficits, recent initiation of a new therapy agent and distinctive findings on magnetic resonance imaging. Clinical and radiological improvement and/or resolution are frequently observed after the agent is discontinued.

Indexed as

AdolescentAngiogenesis InhibitorsAntibodies, Monoclonal, HumanizedAnti-Infective AgentsBevacizumabChild, PreschoolCyclosporineFemaleHumansImmunosuppressive AgentsInfantMagnetic Resonance ImagingMaleMethotrexateMetronidazoleNeurotoxicity SyndromesAngiogenesis InhibitorsAntibodies, Monoclonal, HumanizedAnti-Infective AgentsBevacizumabCyclosporineImmunosuppressive AgentsMethotrexateMetronidazoleTacrolimus

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.