Evidence map›Paper›PMID 21785802›Full record

ArticleLab on a chip2011

Single-cell electrical lysis of erythrocytes detects deficiencies in the cytoskeletal protein network.

Ning Bao, Gayani C Kodippili, Katie M Giger, Velia M Fowler, Philip S Low, Chang Lu

Abstract read
In one paragraph

Article in Lab on a chip, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Microfluidic Electroporation: Recent Advances and Applications.Advances in experimental medicine and biology · 2026
    Review
  2. Review
  3. Review
  4. Dielectrophoretic separation of blood cells.Biomedical microdevices · 2022
    Review
  5. Article
  6. Digital Microfluidics for Manipulation and Analysis of a Single Cell.International journal of molecular sciences · 2015
    Review
  7. High-Throughput Assessment of Cellular Mechanical Properties.Annual review of biomedical engineering · 2015
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ning BaoDepartment of Chemical Engineering, School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA.
Gayani C Kodippili
Katie M Giger
Velia M Fowler
Philip S Low
Chang Lu
Purdue University West Lafayette · USVirginia Tech · USScripps Research Institute · US

Funding

Capping Actin Growth in Erythroid and Nonerythroid CellsR01HL083464 · NHLBI · UNIVERSITY OF DELAWARE · PI FOWLER, VELIA M · 2006 to 2019
$7.1M
Studies of Erythrocyte Membrane StructureR01GM024417 · NIGMS · PURDUE UNIVERSITY WEST LAFAYETTE · PI LOW, PHILIP STEWART · 1985 to 2020
$5.4M
NHLBI NIH HHS R01 HL083464NHLBI NIH HHS R01HL083464NIGMS NIH HHS R01 GM024417NIGMS NIH HHS R01GM024417
6 · The paper itself

Abstract

The network of erythrocyte cytoskeletal proteins significantly influences erythrocyte physical and biological properties. Here we show that the kinetics of erythrocyte lysis during exposure to an electric field is sensitively correlated with defects in the cytoskeletal network. Histograms compiled from single-cell electrical lysis data show characteristics of erythrocyte populations that are deficient in a specific cytoskeletal protein, revealing the presence of cell subpopulations.

Indexed as

AdducinsAnimalsAnkyrinsCalmodulin-Binding ProteinsCell SizeCytoskeletal ProteinsElectroporationErythrocytesHemolysisMiceMice, TransgenicMicrofluidic Analytical TechniquesSingle-Cell AnalysisAdducinsAnkyrinsCalmodulin-Binding ProteinsCytoskeletal Proteins

Identifiers

PMID21785802
PMCPMC3286654
OpenAlexW2148611097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.