ArticleJournal of aging research2011
Cholinergic Degeneration and Alterations in the TrkA and p75NTR Balance as a Result of Pro-NGF Injection into Aged Rats.
Article in Journal of aging research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Modulation of the p75NTR during Adolescent Alcohol Exposure Prevents Cholinergic Neuronal Atrophy and Associated Acetylcholine Activity and Behavioral Dysfunction.International journal of molecular sciences · 2024Article
- Maternal Subclinical Hypothyroidism in Rats Impairs Spatial Learning and Memory in Offspring by Disrupting Balance of the TrkA/p75Molecular neurobiology · 2021Article
- Expression of Selected Genes Involved in Neurogenesis in the Etiopathogenesis of Depressive Disorders.Journal of personalized medicine · 2021Article
- Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration.Scientific reports · 2019Article
- Early Downregulation of p75Molecular neurobiology · 2019Article
- Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.PloS one · 2019Article
- Subclinical hypothyroidism in pregnant rats impaired learning and memory of their offspring by promoting the p75Endocrine connections · 2018Article
- Sevoflurane-induced memory impairment in the postnatal developing mouse brain.Experimental and therapeutic medicine · 2018Article
- Pro-BDNF Contributes to Hypoxia/Reoxygenation Injury in Myocardial Microvascular Endothelial Cells: Roles of Receptors p75Oxidative medicine and cellular longevity · 2018Article
- Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.Journal of Huntington's disease · 2017Review
- Increased Hippocampal ProBDNF Contributes to Memory Impairments in Aged Mice.Frontiers in aging neuroscience · 2017Article
- A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Human molecular genetics · 2016Article
- (-)-Epigallocatechin-3-gallate ameliorates learning and memory deficits by adjusting the balance of TrkA/p75NTR signaling in APP/PS1 transgenic mice.Molecular neurobiology · 2014Article
- Effects of sustained proNGF blockade on attentional capacities in aged rats with compromised cholinergic system.Neuroscience · 2014Article
- Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases.Neurochemical research · 2013Review
- ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice.Cell death and differentiation · 2013Article
- The generation of NGF-secreting primary rat monocytes: a comparison of different transfer methods.Journal of immunological methods · 2013Article
- Vascular and neuronal protection induced by the ocular administration of nerve growth factor in diabetic-induced rat encephalopathy.CNS neuroscience & therapeutics · 2013Article
- Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation.Biochemical and biophysical research communications · 2013Article
- Diminished trkA receptor signaling reveals cholinergic-attentional vulnerability of aging.The European journal of neuroscience · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Learning and memory impairments occurring with Alzheimer's disease (AD) are associated with degeneration of the basal forebrain cholinergic neurons (BFCNs). BFCNs extend their axons to the hippocampus where they bind nerve growth factor (NGF) which is retrogradely transported to the cell body. While NGF is necessary for BFCN survival and function via binding to the high-affinity receptor TrkA, its uncleaved precursor, pro-NGF has been proposed to induce neurodegeneration via binding to the p75NTR and its coreceptor sortilin. Basal forebrain TrkA and NGF are downregulated with aging while pro-NGF is increased. Given these data, the focus of this paper was to determine a mechanism for how pro-NGF accumulation may induce BFCN degeneration. Twenty-four hours after a single injection of pro-NGF into hippocampus, we found increased hippocampal p75NTR levels, decreased hippocampal TrkA levels, and cholinergic degeneration. The data suggest that the increase in p75NTR with AD may be mediated by elevated pro-NGF levels as a result of decreased cleavage, and that pro-NGF may be partially responsible for age-related degenerative changes observed in the basal forebrain. This paper is the first in vivo evidence that pro-NGF can affect BFCNs and may do so by regulating expression of p75NTR neurotrophin receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.