ArticleEvidence-based complementary and alternative medicine : eCAM2012
Hydrotherapy for the treatment of pain in people with multiple sclerosis: a randomized controlled trial.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 9 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Effects of Mind-body Movement Interventions for Managing Symptoms in People with Multiple Sclerosis: An Overview of Reviews.Current neurology and neuroscience reports · 2026Pooled it
- Effects of exercise on fatigue and quality of life in multiple sclerosis: a network meta-analysis and systematic review.Journal of neurology · 2025Pooled it
- Effectiveness of physical activity interventions on reducing perceived fatigue among adults with chronic conditions: a systematic review and meta-analysis of randomised controlled trials.Scientific reports · 2023Pooled it
- Effects of aquatic exercise on the improvement of lower-extremity motor function and quality of life in patients with Parkinson's disease: A meta-analysis.Frontiers in physiology · 2023Pooled it
- Which exercise and behavioural interventions show most promise for treating fatigue in multiple sclerosis? A network meta-analysis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Pooled it
- Non-pharmacological interventions for chronic pain in multiple sclerosis.The Cochrane database of systematic reviews · 2018Pooled it
- Does Tai Chi relieve fatigue? A systematic review and meta-analysis of randomized controlled trials.PloS one · 2017Pooled it
- Exercise therapy for fatigue in multiple sclerosis.The Cochrane database of systematic reviews · 2015Pooled it
- Non pharmacological interventions for spasticity in multiple sclerosis.The Cochrane database of systematic reviews · 2013Pooled it
- Physical function and psychosocial outcomes after a 6-month self-paced aquatic exercise program for individuals with myalgic encephalomyelitis/chronic fatigue syndrome.European journal of applied physiology · 2025Trial
- Effects of aquatic exercises on postural control and hand function in Multiple Sclerosis: Halliwick versus Aquatic Plyometric Exercises: a randomised trial.Journal of musculoskeletal & neuronal interactions · 2020Trial
- Combined upper limb and breathing exercise programme for pain management in ambulatory and non-ambulatory multiple sclerosis individuals: part II analyses from feasibility study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Trial
- Acupuncture Combined with Hydrotherapy in Diabetes Patients with Mild Lower-Extremity Arterial Disease: A Prospective, Randomized, Nonblinded Clinical Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Trial
- The role of exercise in modifying outcomes for people with multiple sclerosis: a randomized trial.BMC neurology · 2013Trial
- Relaxation interventions in neurological rehabilitation: a scoping review.Journal of rehabilitation medicine · 2026Article
- Effects of Aquatic Therapy on Fatigue, Mobility, Physical Function, and Quality of Life in People with Multiple Sclerosis: A Systematic Review and Meta-Analysis.Journal of functional morphology and kinesiology · 2026Review
- Chronic Pain in Multiple Sclerosis: Mechanisms, Clinical Characteristics and Treatment Strategies.International journal of molecular sciences · 2026Review
- Balance and Coordination Improvements in Children and Adolescents with Autism Spectrum Disorder (ASD), Resulting from a Hydrotherapy Intervention.Children (Basel, Switzerland) · 2026Article
- Article
- Aqua polo: Preliminary feasibility and efficacy study of a programme of adapted, supervised water polo to reduce fatigue and improve women's psychological and social recovery after breast cancer treatment: A mixed-methods design.Contemporary clinical trials communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background. Multiple sclerosis (MS) is a chronic demyelinating neurological disease. Several studies have reported that complementary and alternative therapies can have positive effects against pain in these patients. Objective. The objective was to investigate the effectiveness of an Ai-Chi aquatic exercise program against pain and other symptoms in MS patients. Methods. In this randomized controlled trial, 73 MS patients were randomly assigned to an experimental or control group for a 20-week treatment program. The experimental group underwent 40 sessions of Ai-Chi exercise in swimming pool and the control group 40 sessions of abdominal breathing and contraction-relaxation exercises in therapy room. Outcome variables were pain, disability, spasm, depression, fatigue, and autonomy, which were assessed before the intervention and immediately and at 4 and 10 weeks after the last treatment session. Results. The experimental group showed a significant (P < 0.028) and clinically relevant decrease in pain intensity versus baseline, with an immediate posttreatment reduction in median visual analogue scale scores of 50% that was maintained for up to 10 weeks. Significant improvements were also observed in spasm, fatigue, disability, and autonomy. Conclusion. According to these findings, an Ai-Chi aquatic exercise program improves pain, spasms, disability, fatigue, depression, and autonomy in MS patients.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.