ArticleJournal of biomedicine & biotechnology2011
Clinical therapeutics in pregnancy.
Article in Journal of biomedicine & biotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Enantiomer-specific ketorolac pharmacokinetics in young women, including pregnancy and postpartum period.Bosnian journal of basic medical sciences · 2017Trial
- Bedaquiline exposure in pregnancy and breastfeeding in women with rifampicin-resistant tuberculosis.British journal of clinical pharmacology · 2022Article
- The Person's Care Requires a Sex and Gender Approach.Journal of clinical medicine · 2021Review
- Using a Composite Maternal-Infant Outcome Measure in Tuberculosis-Prevention Studies Among Pregnant Women.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Sources of Interindividual Variability.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Maternal Serotonin Reuptake Inhibitor Antidepressants Have Acute Effects on Fetal Heart Rate Variability in Late Gestation.Frontiers in psychiatry · 2021Article
- Maternal Pharmacokinetics and Fetal Disposition of (±)-Citalopram during Mouse Pregnancy.ACS chemical neuroscience · 2016Article
- Maternal-fetal disposition of glyburide in pregnant mice is dependent on gestational age.The Journal of pharmacology and experimental therapeutics · 2014Article
- Perinatal pharmacology.BioMed research international · 2014Article
- A simplified PBPK modeling approach for prediction of pharmacokinetics of four primarily renally excreted and CYP3A metabolized compounds during pregnancy.The AAPS journal · 2013Article
- The impact of pregnancy on urinary ketorolac metabolites after single intravenous bolus.European journal of drug metabolism and pharmacokinetics · 2013Article
- Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice.Drug metabolism and disposition: the biological fate of chemicals · 2013Article
- Drug metabolism and transport during pregnancy: how does drug disposition change during pregnancy and what are the mechanisms that cause such changes?Drug metabolism and disposition: the biological fate of chemicals · 2013Article
- The status of pharmacometrics in pregnancy: highlights from the 3(rd) American conference on pharmacometrics.British journal of clinical pharmacology · 2012Review
- Pharmacokinetics of tacrolimus during pregnancy.Therapeutic drug monitoring · 2012Article
- Pharmacokinetic optimization of antiretroviral therapy in pregnancy.Clinical pharmacokinetics · 2012Review
- Effective analgesia after cesarean delivery needs pharmacokinetic input.Journal of anaesthesiology, clinical pharmacology · 2012Article
- The impact of Caesarean delivery on paracetamol and ketorolac pharmacokinetics: a paired analysis.Journal of biomedicine & biotechnology · 2012Article
- Effect of Maternal Obesity on Maternal-Fetal Transfer of Preoperative Cefazolin at Cesarean Section.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most drugs are not tested for use during pregnancy, consequently, labeling, which may include information about fetal safety, includes nothing about dosing, efficacy, or maternal safety. Yet these are concerns of health care providers considering treatment of disease during pregnancy. Therefore, the practitioner treats the pregnant woman with the same dose recommended for use in adults (typically men) or may decide not to treat the disease at all. However, is the choice of not treating a woman during pregnancy better than dealing with the challenges which accompany treatment? This paper, which summarizes metabolic and physiologic changes induced by pregnancy, illustrates that standard adult dosing is likely to be incorrect during pregnancy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.