ArticleNature cell biology2011
Cytoskeletal polarity mediates localized induction of the heart progenitor lineage.
Article in Nature cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 48 citations in OpenAlex.
- The Role of TPM3 in Protecting Cardiomyocyte from Hypoxia-Induced Injury via Cytoskeleton Stabilization.International journal of molecular sciences · 2024Article
- Lhx3/4 initiates a cardiopharyngeal-specific transcriptional program in response to widespread FGF signaling.PLoS biology · 2024Article
- Single-nucleotide variants within heart enhancers increase binding affinity and disrupt heart development.Developmental cell · 2023Article
- Establishment and identification of cardiomyocyte arhGEF18 gene conditional knockout mice.Pediatric discovery · 2023Article
- Cyclin-dependent Kinase 1 and Aurora Kinase choreograph mitotic storage and redistribution of a growth factor receptor.PLoS biology · 2021Article
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- Review
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- Dynamic interplay of cell fate, polarity and force generation in ascidian embryos.Current opinion in genetics & development · 2018Review
- An FGF-driven feed-forward circuit patterns the cardiopharyngeal mesoderm in space and time.eLife · 2018Article
- Transgenic Techniques for Investigating Cell Biology During Development.Advances in experimental medicine and biology · 2018Review
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- Article
- Regulation and evolution of cardiopharyngeal cell identity and behavior: insights from simple chordates.Current opinion in genetics & development · 2015Review
- Surrounding tissues canalize motile cardiopharyngeal progenitors towards collective polarity and directed migration.Development (Cambridge, England) · 2015Article
- MicroRNA Clusters in the Adult Mouse Heart: Age-Associated Changes.BioMed research international · 2015Article
- Quantitative and in toto imaging in ascidians: working toward an image-centric systems biology of chordate morphogenesis.Genesis (New York, N.Y. : 2000) · 2015Review
- Multiparametric classification links tumor microenvironments with tumor cell phenotype.PLoS biology · 2014Article
- Invadosomes in their natural habitat.European journal of cell biology · 2014Review
- Collier/OLF/EBF-dependent transcriptional dynamics control pharyngeal muscle specification from primed cardiopharyngeal progenitors.Developmental cell · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Cells must make appropriate fate decisions within a complex and dynamic environment. In vitro studies indicate that the cytoskeleton acts as an integrative platform for this environmental input. External signals regulate cytoskeletal dynamics and the cytoskeleton reciprocally modulates signal transduction. However, in vivo studies linking cytoskeleton/signalling interactions to embryonic cell fate specification remain limited. Here we show that the cytoskeleton modulates heart progenitor cell fate. Our studies focus on differential induction of heart fate in the basal chordate Ciona intestinalis. We have found that differential induction does not simply reflect differential exposure to the inductive signal. Instead, pre-cardiac cells employ polarized, invasive protrusions to localize their response to an ungraded signal. Through targeted manipulation of the cytoskeletal regulator CDC42, we are able to depolarize protrusive activity and generate uniform heart progenitor fate specification. Furthermore, we are able to restore differential induction by repolarizing protrusive activity. These findings illustrate how bi-directional interactions between intercellular signalling and the cytoskeleton can influence embryonic development. In particular, these studies highlight the potential for dynamic cytoskeletal changes to refine cell fate specification in response to crude signal gradients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.