ReviewCurrent opinion in gastroenterology2011
Iron and intestinal immunity.
Review in Current opinion in gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- High Dietary Carbonyl Iron Reshapes the Gut Microbiome and Impairs Hepatic Insulin Sensitivity in a Time-Dependent Manner.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Association between serum iron and gallstones in US adults: a cross-sectional study.BMC nutrition · 2024Article
- Differential gut microbiota composition in β-Thalassemia patients and its correlation with iron overload.Scientific reports · 2024Article
- Regulation of a High-Iron Diet on Lipid Metabolism and Gut Microbiota in Mice.Animals : an open access journal from MDPI · 2022Article
- Review
- Iron Supplementation Influence on the Gut Microbiota and Probiotic Intake Effect in Iron Deficiency-A Literature-Based Review.Nutrients · 2020Review
- Dietary iron variably modulates assembly of the intestinal microbiota in colitis-resistant and colitis-susceptible mice.Gut microbes · 2020Article
- Testing an infection model to explain excess risk of preterm birth with long-term iron supplementation in a malaria endemic area.Malaria journal · 2019Article
- Transition metals and host-microbe interactions in the inflamed intestine.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2019Review
- Serum iron concentration as a marker of inflammation in young cows that underwent dehorning operation.The Journal of veterinary medical science · 2019Article
- Sequential changes in serum zinc concentrations in calves with experimentally induced endotoxin shock measured by the particle-induced X-ray emission method.The Journal of veterinary medical science · 2019Article
- Established and Emerging Concepts to Treat Imbalances of Iron Homeostasis in Inflammatory Diseases.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Gut Microbiota and Iron: The Crucial Actors in Health and Disease.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Prenatal iron exposure and childhood type 1 diabetes.Scientific reports · 2018Article
- Genome-Wide Identification by Transposon Insertion Sequencing of Escherichia coli K1 Genes Essential forJournal of bacteriology · 2018Article
- Iron Dysregulation and Dormant Microbes as Causative Agents for Impaired Blood Rheology and Pathological Clotting in Alzheimer's Type Dementia.Frontiers in neuroscience · 2018Review
- Pathophysiology of Iron Homeostasis during Inflammatory States.The Journal of pediatrics · 2015Review
- Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogens.European journal of immunology · 2015Article
- Bacterial iron-sulfur cluster sensors in mammalian pathogens.Metallomics : integrated biometal science · 2015Review
- Association between maternal iron supplementation during pregnancy and risk of celiac disease in children.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewRecent advances in the study of iron metabolism have led to a better understanding of the molecular basis for the interactions between iron and the inflammatory response. We will review this new information in the context of the gastrointestinal tract. RECENT
findingsThe effects of iron on microbial enteropathogens are well known. Recent work has demonstrated that iron also has potentially important effects on the intestinal microbiota. On the host side, hepcidin, a key regulator of mammalian iron metabolism, has emerged as an important mediator of the cross-talk between iron homeostasis and inflammation. Hepcidin-dependent changes in iron flux can influence the expression of inflammatory cytokines, and conversely, inflammatory cytokines can induce hepcidin expression and alter iron homeostasis. Hepcidin levels have been found to be elevated in some studies of inflammatory bowel disease, while manipulating hepcidin expression in animal models of this condition has beneficial effects on both inflammation and dysregulated iron metabolism. SUMMARY: The information on iron metabolism that has become available in recent years has shed new light on the pathogenesis of inflammatory diseases of the gastrointestinal tract, and is also starting to suggest new approaches to treating such diseases.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.