ArticleThe Journal of clinical investigation2011
Fatty acid-induced gut-brain signaling attenuates neural and behavioral effects of sad emotion in humans.
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Intragastric Fatty Acid Infusion on Behavioral Responses to Positive Emotion Induction in Normal Weight Subjects
Effect of Intragastric Administration of Fatty Acids on Generalized Reward Sensitivity
Who cites it
35 citing papers in PubMed, 84 citations in OpenAlex.
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- Gut microbiota shapes the effects of saturated and polyunsaturated fatty acids on skin and hair follicle homeostasis.The Journal of investigative dermatology · 2026Article
- Integrating Gut-Brain Axis: Exploring the Neurogastrointestinal Interactions and Therapeutic Potentials in Autism Spectrum Disorder.Endocrine, metabolic & immune disorders drug targets · 2026Review
- The gut and heart's role in reward processing.Frontiers in integrative neuroscience · 2025Review
- Dietary changes as a risk factor and remedy for meditation-related challenges.Frontiers in nutrition · 2025Article
- Depressed mood affects the process of biological aging, analyses from the NHANES dataset.Frontiers in aging · 2025Review
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- Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers.Cell reports. Medicine · 2023Article
- The Impact of Various Methods of Obesity Treatment on the Quality of Life and Mental Health-A Narrative Review.International journal of environmental research and public health · 2023Review
- Gut Microbiota and Neuroplasticity.Cells · 2021Review
- Biological mechanisms underlying widowhood's health consequences: Does diet play a role?Comprehensive psychoneuroendocrinology · 2021Review
- Glutamate and depression: Reflecting a deepening knowledge of the gut and brain effects of a ubiquitous molecule.World journal of psychiatry · 2021Review
- Brain activation after nasal histamine provocation in house dust mite allergic rhinitis patients.Allergy · 2021Article
- The Gut-Brain Axis and Its Role in Controlling Eating Behavior in Intestinal Inflammation.Nutrients · 2021Review
- Anxiety Sensitivity and Fast-Food Ordering Habits Among Black Adults.Health behavior research · 2021Article
- Diet, Stress and Mental Health.Nutrients · 2020Review
- Evolution, the Menstrual Cycle, and Theoretical Overreach.Perspectives on psychological science : a journal of the Association for Psychological Science · 2020Article
- Acute but Not Permanent Effects of Propranolol on Fear Memory Expression in Humans.Frontiers in human neuroscience · 2019Article
- Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders.Journal of neurogastroenterology and motility · 2018Review
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Although a relationship between emotional state and feeding behavior is known to exist, the interactions between signaling initiated by stimuli in the gut and exteroceptively generated emotions remain incompletely understood. Here, we investigated the interaction between nutrient-induced gut-brain signaling and sad emotion induced by musical and visual cues at the behavioral and neural level in healthy nonobese subjects undergoing functional magnetic resonance imaging. Subjects received an intragastric infusion of fatty acid solution or saline during neutral or sad emotion induction and rated sensations of hunger, fullness, and mood. We found an interaction between fatty acid infusion and emotion induction both in the behavioral readouts (hunger, mood) and at the level of neural activity in multiple pre-hypothesized regions of interest. Specifically, the behavioral and neural responses to sad emotion induction were attenuated by fatty acid infusion. These findings increase our understanding of the interplay among emotions, hunger, food intake, and meal-induced sensations in health, which may have important implications for a wide range of disorders, including obesity, eating disorders, and depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.