ArticleThe Journal of clinical investigation2011
Quantity, not quality, of antibody response decreased in the elderly.
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 38 citations in OpenAlex.
- COVID-19 Vaccination Enhances the Immunogenicity of Seasonal Influenza Vaccination in the Elderly.Vaccines · 2025Article
- Genetic differences in the HLA region contribute to the variability in SARS-CoV-2 vaccine responsiveness of older persons: the Doetinchem Cohort Study.Clinical & translational immunology · 2025Article
- Incidence and risk factors of omicron variant SARS-CoV-2 breakthrough infection among vaccinated and boosted individuals.medRxiv : the preprint server for health sciences · 2024Article
- Article
- Impact of SARS-CoV-2 pandemic on rehabilitation of patients after high-dose chemotherapy with allogeneic hematopoietic stem cell transplantation: results of a monocentric, retrospective analysis.Journal of cancer research and clinical oncology · 2023Article
- Population differences in antibody response to SARS-CoV-2 infection and BNT162b2 vaccination.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- SARS-CoV-2 antibody response after mRNA vaccination in healthcare workers with and without previous COVID-19, a follow-up study from a university hospital in Poland during 6 months 2021.Frontiers in immunology · 2022Article
- The dark side of Tregs during aging.Frontiers in immunology · 2022Review
- Age-Dependent Reduction in Neutralization against Alpha and Beta Variants of BNT162b2 SARS-CoV-2 Vaccine-Induced Immunity.Microbiology spectrum · 2021Article
- Preexisting subtype immunodominance shapes memory B cell recall response to influenza vaccination.JCI insight · 2020Article
- IgA Responses Following Recurrent Influenza Virus Vaccination.Frontiers in immunology · 2020Article
- Immunological considerations in the development ofHuman vaccines & immunotherapeutics · 2020Review
- The poly-omics of ageing through individual-based metabolic modelling.BMC bioinformatics · 2018Article
- Article
- Immune senescence: significance of the stromal microenvironment.Clinical and experimental immunology · 2017Review
- Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses.Scientific reports · 2016Article
- T cell responses to viral infections - opportunities for Peptide vaccination.Frontiers in immunology · 2014Review
- Immunosenescence and novel vaccination strategies for the elderly.Frontiers in immunology · 2013Article
- AID activity in B cells strongly correlates with polyclonal antibody affinity maturation in-vivo following pandemic 2009-H1N1 vaccination in humans.PLoS pathogens · 2012Article
- Influenza virus H1N1pdm09 infections in the young and old: evidence of greater antibody diversity and affinity for the hemagglutinin globular head domain (HA1 Domain) in the elderly than in young adults and children.Journal of virology · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The burden of disease during seasonal influenza epidemics is felt most keenly among the very young and the elderly. Although vaccination effectively protects children and young adults against infection, it has limited efficacy in elderly individuals. This has been linked to a reduced ability to induce a robust serum antibody response. In this issue of the JCI, Sasaki et al. identify some of the cellular and molecular deficits that underlie the reduced serum antibody response induced by influenza vaccination in elderly individuals. Importantly, they show that it is the quantity of the response, and not its quality, that needs to be improved if we are to enhance the success of influenza vaccination in this vulnerable population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.