ArticleProceedings of the National Academy of Sciences of the United States of America2011
Combinatorial synthesis of chemically diverse core-shell nanoparticles for intracellular delivery.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed.
- Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity.Nature biomedical engineering · 2025Article
- Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Advances in RNA-based therapeutics: current breakthroughs, clinical translation, and future perspectives.Frontiers in genetics · 2025Review
- Recyclable Thermoplastic Elastomer from Furan Functionalized Hairy Nanoparticles with Polystyrene Core and Polydimethylsiloxane Hairs.Polymers · 2024Article
- Combination of Physicochemical Tropism and Affinity Moiety Targeting of Lipid Nanoparticles Enhances Organ Targeting.Nano letters · 2024Article
- Nanobiotechnology-Enabled mRNA Stabilization.Pharmaceutics · 2023Review
- RGD peptide-based lipids for targeted mRNA delivery and gene editing applications.RSC advances · 2022Article
- Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo.Nature communications · 2022Article
- Non-viral delivery of CRISPR-Cas9 complexes for targeted gene editing via a polymer delivery system.Gene therapy · 2022Article
- Power in Numbers: Harnessing Combinatorial and Integrated Screens to Advance Nanomedicine.JACS Au · 2022Review
- Improvement of High-Throughput Experimentation Using Synthesis Robots by the Implementation of Tailor-Made Sensors.Polymers · 2022Article
- Dual pH-Responsive and Tumor-Targeted Nanoparticle-Mediated Anti-Angiogenesis siRNA Delivery for Tumor Treatment.International journal of nanomedicine · 2022Article
- Zwitterionic Phospholipidation of Cationic Polymers Facilitates Systemic mRNA Delivery to Spleen and Lymph Nodes.Journal of the American Chemical Society · 2021Article
- Non-Cationic RGD-Containing Protein Nanocarrier for Tumor-Targeted siRNA Delivery.Pharmaceutics · 2021Article
- Chitosan Oleate Coated PLGA Nanoparticles as siRNA Drug Delivery System.Pharmaceutics · 2021Article
- High-throughput screening of nanoparticles in drug delivery.APL bioengineering · 2021Review
- Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs.Nature biomedical engineering · 2021Article
- PEI fluorination reduces toxicity and promotes liver-targeted siRNA delivery.Drug delivery and translational research · 2021Article
- A comparative study of the self-assembly of achiral and chiral hairy nanoparticles with polystyrene cores and poly(2-hydroxyethylmethacrylate) hairs.RSC advances · 2020Article
- Targeting prenylation inhibition through the mevalonate pathway.RSC medicinal chemistry · 2020Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
Analogous to an assembly line, we employed a modular design for the high-throughput study of 1,536 structurally distinct nanoparticles with cationic cores and variable shells. This enabled elucidation of complexation, internalization, and delivery trends that could only be learned through evaluation of a large library. Using robotic automation, epoxide-functionalized block polymers were combinatorially cross-linked with a diverse library of amines, followed by measurement of molecular weight, diameter, RNA complexation, cellular internalization, and in vitro siRNA and pDNA delivery. Analysis revealed structure-function relationships and beneficial design guidelines, including a higher reactive block weight fraction, stoichiometric equivalence between epoxides and amines, and thin hydrophilic shells. Cross-linkers optimally possessed tertiary dimethylamine or piperazine groups and potential buffering capacity. Covalent cholesterol attachment allowed for transfection in vivo to liver hepatocytes in mice. The ability to tune the chemical nature of the core and shell may afford utility of these materials in additional applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.