ArticleThe Plant cell2011
Perturbation of Arabidopsis amino acid metabolism causes incompatibility with the adapted biotrophic pathogen Hyaloperonospora arabidopsidis.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 118 citations in OpenAlex.
- Bacillus-mediated transcriptional and metabolic reprogramming elicits defense priming in Coptis chinensis roots.Scientific reports · 2026Article
- Article
- Enhancing Plant Resistance to Sri Lankan Cassava Mosaic Virus Using Salicylic Acid.Metabolites · 2025Article
- Rice Varieties Intercropping Induced Soil Metabolic and Microbial Recruiting to Enhance the Rice Blast (Metabolites · 2024Article
- Holomics - a user-friendly R shiny application for multi-omics data integration and analysis.BMC bioinformatics · 2024Article
- Metabolomics and Transcriptomics Reveal the Response Mechanisms ofMicroorganisms · 2023Article
- DROUGHT-INDUCED BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE enhances drought tolerance in rice.Plant physiology · 2023Article
- Impact of high atmospheric carbon dioxide on the biotic stress response of the model cereal speciesFrontiers in plant science · 2023Article
- The Hidden Potential of High-Throughput RNA-Seq Re-Analysis, a Case Study for DHDPS, Key Enzyme of the Aspartate-Derived Lysine Biosynthesis Pathway and Its Role in Abiotic and Biotic Stress Responses in Soybean.Plants (Basel, Switzerland) · 2022Article
- New Insight into Aspartate Metabolic Pathways inInternational journal of molecular sciences · 2022Article
- Deciphering the Molecular Signatures Associated With Resistance toFrontiers in plant science · 2022Article
- Insect eggs trigger systemic acquired resistance against a fungal and an oomycete pathogen.The New phytologist · 2021Article
- High-efficiency genome editing in plants mediated by a Cas9 gene containing multiple introns.Plant communications · 2021Article
- A holistic view on plant effector-triggered immunity presented as an iceberg model.Cellular and molecular life sciences : CMLS · 2020Review
- Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity.Molecular plant · 2020Article
- Article
- Increased Expression of UMAMIT Amino Acid Transporters Results in Activation of Salicylic Acid Dependent Stress Response.Frontiers in plant science · 2020Article
- Article
- An EDS1-SAG101 Complex Is Essential for TNL-Mediated Immunity inThe Plant cell · 2019Article
- A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors.The Plant cell · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reliance of biotrophic pathogens on living plant tissues to propagate implies strong interdependence between host metabolism and nutrient uptake by the pathogen. However, factors determining host suitability and establishment of infection are largely unknown. We describe a loss-of-inhibition allele of ASPARTATE KINASE2 and a loss-of-function allele of DIHYDRODIPICOLINATE SYNTHASE2 identified in a screen for Arabidopsis thaliana mutants with increased resistance to the obligate biotrophic oomycete Hyaloperonospora arabidopsidis (Hpa). Through different molecular mechanisms, these mutations perturb amino acid homeostasis leading to overaccumulation of the Asp-derived amino acids Met, Thr, and Ile. Although detrimental for the plant, the mutations do not cause defense activation, and both mutants retain full susceptibility to the adapted obligate biotrophic fungus Golovinomyces orontii (Go). Chemical treatments mimicking the mutants' metabolic state identified Thr as the amino acid suppressing Hpa but not Go colonization. We conclude that perturbations in amino acid homeostasis render the mutant plants unsuitable as an infection substrate for Hpa. This may be explained by deployment of the same amino acid biosynthetic pathways by oomycetes and plants. Our data show that the plant host metabolic state can, in specific ways, influence the ability of adapted biotrophic strains to cause disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.