ArticleExperimental physiology2011
Brachial artery vasodilatation during prolonged lower limb exercise: role of shear rate.
Article in Experimental physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 78 citations in OpenAlex.
- One Year of Endurance Exercise Training Does not Improve Vascular Function in Non-Trained Limbs in Healthy Individuals.Scandinavian journal of medicine & science in sports · 2026Article
- A single bout of submaximal aerobic functional capacity test acutely promotes endothelial function in long COVID patients.Scientific reports · 2026Article
- Increases in skin perfusion and blood oxygen in the non-exercising human limbs during exercise in the heat: Implications for control of circulation.Experimental physiology · 2025Article
- Functional sympatholysis of neuropeptide Y-mediated vasoconstriction in humans.The Journal of physiology · 2025Article
- Adrenergic control of skeletal muscle blood flow during chronic hypoxia in healthy males.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Impact of acute dynamic exercise and arterial shear rate modification on radial artery low-flow mediated constriction in young men.European journal of applied physiology · 2022Article
- Passive leg movement-induced vasodilation and exercise-induced sympathetic vasoconstriction.Autonomic neuroscience : basic & clinical · 2022Article
- Effects of Unilateral Arm Warming or Cooling on the Modulation of Brachial Artery Shear Stress and Endothelial Function during Leg Exercise in Humans.Journal of atherosclerosis and thrombosis · 2021Article
- Hemodynamics of post-exercise vs. post hot water immersion recovery.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Could the arm blood pressure measured with simultaneous bilateral arm method be used for hypertension diagnosis?BMJ open · 2020Article
- Functional sympatholysis is preserved in healthy young Black men during rhythmic handgrip exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Mechanisms of sympathetic restraint in human skeletal muscle during exercise: role of α-adrenergic and nonadrenergic mechanisms.American journal of physiology. Heart and circulatory physiology · 2020Article
- Effect of sinusoidal leg cycling exercise period on brachial artery blood flow dynamics in humans.The journal of physiological sciences : JPS · 2020Article
- Heat therapy reduces sympathetic activity and improves cardiovascular risk profile in women who are obese with polycystic ovary syndrome.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Swimming-related effects on cerebrovascular and cognitive function.Physiological reports · 2019Article
- Effects of dynamic arm and leg exercise on muscle sympathetic nerve activity and vascular conductance in the inactive leg.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Increased endothelial shear stress improves insulin-stimulated vasodilatation in skeletal muscle.The Journal of physiology · 2019Article
- Attenuated forearm vascular conductance responses to rhythmic handgrip in young African-American compared with Caucasian-American men.American journal of physiology. Heart and circulatory physiology · 2018Article
- Vascular Response During Mental Stress in Sedentary and Physically Active Patients With Obstructive Sleep Apnea.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- Exercise-Derived Microvesicles: A Review of the Literature.Sports medicine (Auckland, N.Z.) · 2018Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We recently observed a marked increase in brachial artery (BA) diameter during prolonged leg cycling exercise. The purpose of the present study was to test the hypothesis that this increase in BA diameter during lower limb exercise is shear stress mediated. Accordingly, we determined whether recapitulation of cycling-induced BA shear rate with forearm heating, a known stimulus evoking shear-induced conduit artery dilatation, would elicit comparable profiles and magnitudes of BA vasodilatation to those observed during cycling. In 12 healthy men, BA diameter and blood velocity were measured simultaneously using Doppler ultrasonography at baseline and every 5 min during 60 min of either steady-state semi-recumbent leg cycling (120 W) or forearm heating. At the onset of cycling, the BA diameter was reduced (-3.9 ± 1.2% at 5 min; P < 0.05), but it subsequently increased throughout the remainder of the exercise bout (+15.1 ± 1.6% at 60 min; P < 0.05). The increase in BA diameter during exercise was accompanied by an approximately 2.5-fold rise in BA mean shear rate (P < 0.05). Similar increases in BA mean shear with forearm heating elicited an equivalent magnitude of BA vasodilatation to that observed during cycling (P > 0.05). Herein, we found that in the absence of exercise the extent of the BA vasodilator response was reproduced when the BA was exposed to comparable magnitudes of shear rate via forearm heating. These results are consistent with the hypothesis that shear stress plays a key role in signalling brachial artery vasodilatation during dynamic leg exercise.
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