Evidence map›Paper›PMID 21784698›Full record

ReviewCurrent opinion in microbiology2011

Molecular mechanism of Aspergillus fumigatus adherence to host constituents.

Donald C Sheppard

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 106 citations in OpenAlex.

  1. Review
  2. α-1,3-Glucan-Driven Remodeling of the Conidial Cell Wall in anJournal of the American Chemical Society · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Role of theJournal of fungi (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Benzyl isothiocyanate improves the prognosis ofFrontiers in microbiology · 2023
    Article
  14. Review
  15. Article
  16. Review
  17. Journal of fungi (Basel, Switzerland) · 2022
    Review
  18. Review
  19. Growth ofJournal of fungi (Basel, Switzerland) · 2022
    Review
  20. Distinct Cohorts ofFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Donald C SheppardDepartments of Medicine, and Microbiology and Immunology, McGill University, Duff Medical Building, 3775 University St, Rm D22, Montreal, Qc H3A 2B4, Canada. donald.sheppard@mcgill.ca
McGill University · CA

Funding

Transcriptional regulation of A. fumigatus virulenceR01AI073829 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G · 2007 to 2015
$2.8M
CIHRNIAID NIH HHS R01 AI073829NIAID NIH HHS R01AI073829
6 · The paper itself

Abstract

Inhaled conidia of Aspergillus fumigatus rapidly adhere to pulmonary epithelial cells and other host constituents. Identifying molecular mechanisms underlying A. fumigatus adherence has therefore been the focus of a number of studies aimed at identifying novel therapeutic targets. Early studies of A. fumigatus adherence to host constituents focused on fungal proteins, including RodA and AspF2. None of these proteins however has been found to play a role in virulence in experimental animal models. Recent advances have suggested an important role for fungal carbohydrate components of the cell wall and extracellular matrix in adherence, including sialic acid and mannose residues, and the newly described polysaccharide galactosaminogalactan. Despite these advances, the host cell receptors that are bound by these ligands remain unknown.

Indexed as

Host-Pathogen InteractionsAnimalsAspergillus fumigatusCell AdhesionCell WallExtracellular Matrix ProteinsFungal ProteinsGene Expression Regulation, FungalGenes, FungalHumansHyphaeInvasive Pulmonary AspergillosisPolysaccharidesSpores, FungalExtracellular Matrix ProteinsFungal ProteinsgalactosaminogalactanPolysaccharides

Identifiers

PMID21784698
PMCPMC3370656
OpenAlexW2039342879

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.