ArticleThe Journal of urology2011
Ultrastructural investigation of crystal deposits in Npt2a knockout mice: are they similar to human Randall's plaques?
Article in The Journal of urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- FASLG Derived from Fibroblasts in Hydroxyapatite-Rich Microenvironment Induces Urothelial Anoikis to Trigger Randall's Plaque Exposure.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The effects of elevated phosphate on the kidney - damaging the gatekeeper.Pflugers Archiv : European journal of physiology · 2026Review
- Vitamin DScientific reports · 2024Article
- The Protective Role of Dietary Polyphenols in Urolithiasis: Insights into Antioxidant Effects and Mechanisms of Action.Nutrients · 2023Review
- α-Klotho released from HK-2 cells inhibits osteogenic differentiation of renal interstitial fibroblasts by inactivating the Wnt-β-catenin pathway.Cellular and molecular life sciences : CMLS · 2021Article
- Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation.Nature reviews. Nephrology · 2021Review
- Article
- A Drosophila genetic model of nephrolithiasis: transcriptional changes in response to diet induced stone formation.BMC urology · 2017Article
- Histological aspects of the "fixed-particle" model of stone formation: animal studies.Urolithiasis · 2017Review
- Timelines of the "free-particle" and "fixed-particle" models of stone-formation: theoretical and experimental investigations.Urolithiasis · 2017Review
- Article
- Genome-Wide Gene Expression Profiling of Randall's Plaques in Calcium Oxalate Stone Formers.Journal of the American Society of Nephrology : JASN · 2017Article
- Impaired urinary osteopontin excretion in Npt2a-/- mice.American journal of physiology. Renal physiology · 2017Article
- Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice.PloS one · 2017Article
- Calcium Oxalate Stone Fragment and Crystal Phagocytosis by Human Macrophages.The Journal of urology · 2016Article
- Kidney stones.Nature reviews. Disease primers · 2016Review
- Unified theory on the pathogenesis of Randall's plaques and plugs.Urolithiasis · 2015Article
- Biomimetic Randall's plaque as an in vitro model system for studying the role of acidic biopolymers in idiopathic stone formation.Urolithiasis · 2015Article
- Interstitial calcinosis in renal papillae of genetically engineered mouse models: relation to Randall's plaques.Urolithiasis · 2015Review
- The kidney sodium-phosphate co-transporter alters bone quality in an age and gender specific manner.Bone · 2013Article
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2 authors at 1 institution in 1 country.
Funding
Abstract
purposeIdiopathic Ca oxalate stones may develop with attachment to renal interstitial Ca phosphate deposits (Randall's plaques). Sodium phosphate cotransporter (Npt2a) null mice have hypercalciuria and hyperphosphaturia, and produce tubular and interstitial Ca phosphate deposits. To determine whether this mouse is suitable for Randall's plaque investigations we chronologically studied Ca phosphate deposit sites, structure and composition. MATERIALS AND
methodsThe kidneys of Npt2a null mice 2 days to 1 year old were examined by light, scanning and transmission electron microscopy. Electron diffraction and energy dispersive x-ray microanalyses were done to determine mineral composition.
resultsPoorly crystalline, biological apatite deposits were seen in collecting duct lumina. Deposits consisted of aggregates approximately 5 μm in diameter appearing as microspheres of concentrically organized needle or plate-like, matrix rich crystals. Epithelium/crystal interfaces were filled with membrane bound vesicles. Some tubules were completely occluded by crystals and occasionally lost the epithelium while crystals moved into the interstitium.
conclusionsCa phosphate crystals formed in the tubular lumina and were organized as microspheres. The aggregation of Ca phosphate crystals produced nuclei, which grew by adding crystals at the periphery. They eventually became large enough to occlude the tubular lumina and obliterate the tubular epithelium, leading to the relocation of microliths into the interstitium. The pathogenesis of interstitial deposits in Npt2a null mice appears different from that proposed for Randall's plaques. Since Npt2a null mice purge the renal crystal deposits, these mice may serve as a model in which to investigate the elimination of crystal deposits in children and adults with nephrocalcinosis.
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