Trial reportThe Journal of pediatrics2011
Factors affecting growth in infants with single ventricle physiology: a report from the Pediatric Heart Network Infant Single Ventricle Trial.
Trial report in The Journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 107 citations in OpenAlex.
- Somatic growth in single ventricle patients: A systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2023Pooled it
- Nutrition algorithms for infants with hypoplastic left heart syndrome; birth through the first interstage period.Congenital heart diseaseGuideline
- Passive range of motion exercise to enhance growth in infants following the Norwood procedure: a safety and feasibility trial.Cardiology in the young · 2017Trial
- Growth Asymmetry, Head Circumference, and Neurodevelopmental Outcomes in Infants with Single Ventricles.The Journal of pediatrics · 2016Trial
- Randomized Clinical Trial of Preoperative Feeding to Evaluate Intestinal Barrier Function in Neonates Requiring Cardiac Surgery.The Journal of pediatrics · 2015Trial
- Longitudinal assessment of growth in hypoplastic left heart syndrome: results from the single ventricle reconstruction trial.Journal of the American Heart Association · 2014Trial
- Feeding dysfunction in children with single ventricle following staged palliation.The Journal of pediatrics · 2014Trial
- Variation in feeding practices following the Norwood procedure.The Journal of pediatrics · 2014Trial
- Association of impaired linear growth and worse neurodevelopmental outcome in infants with single ventricle physiology: a report from the pediatric heart network infant single ventricle trial.The Journal of pediatrics · 2013Trial
- Early enteral nutrition therapy in congenital cardiac repair postoperatively: A randomized, controlled pilot study.Annals of cardiac anaesthesiaTrial
- Factors Influencing Weight Gain at Different Stages of the Fontan Pathway for Children with Functionally Single Ventricle Heart Disease.Pediatric cardiology · 2026Article
- Growth Failure in Children with Congenital Heart Disease.Children (Basel, Switzerland) · 2025Review
- Experiences in Tube Weaning Children with Congenital Heart Disease and Oral Feeding Aversion.Pediatric cardiology · 2025Article
- Developmental care pathway for hospitalised infants with CHD: on behalf of the Cardiac Newborn Neuroprotective Network, a Special Interest Group of the Cardiac Neurodevelopmental Outcome Collaborative.Cardiology in the young · 2023Article
- Neighborhood Social Vulnerability and Interstage Weight Gain: Evaluating the Role of a Home Monitoring Program.Journal of the American Heart Association · 2023Article
- Enteral access and reflux management in neonates with severe univentricular congenital heart disease: literature review and proposed algorithm.European journal of pediatrics · 2023Review
- Moderate and Severe Congenital Heart Diseases Adversely Affect the Growth of Children in Italy: A Retrospective Monocentric Study.Nutrients · 2023Article
- Telehealth education improves parental care ability and postoperative nutritional status of infants after CHD surgery: A prospective randomized controlled study.Paediatrics & child health · 2022Article
- Risk factors for insufficient weight and height gain in children with congenital heart disease followed up at a nutrition outpatient clinic.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022Article
- Standardized Feeding Approach Mitigates Weight Loss in Infants with Congenital Heart Disease.The Journal of pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 10 institutions in 2 countries.
Funding
Abstract
objectivesTo describe growth patterns in infants with single ventricle physiology and determine factors influencing growth. STUDY
designData from 230 subjects enrolled in the Pediatric Heart Network Infant Single Ventricle Enalapril Trial were used to assess factors influencing change in weight-for-age z-score (z) from study enrollment (0.7 ± 0.4 months) to pre-superior cavopulmonary connection (SCPC; 5.1 ± 1.8 months, period 1) and pre-SCPC to final study visit (14.1 ± 0.9 months, period 2). Predictor variables included patient characteristics, feeding regimen, clinical center, and medical factors during neonatal (period 1) and SCPC hospitalizations (period 2). Univariate regression analysis was performed, followed by backward stepwise regression and bootstrapping reliability to inform a final multivariable model.
resultsWeights were available for 197 of 230 subjects for period 1 and 173 of 197 subjects for period 2. For period 1, greater gestational age, younger age at study enrollment, tube feeding at neonatal hospitalization discharge, and clinical center were associated with a greater negative z (poorer growth) in multivariable modeling (adjusted R(2) = 0.39, P < .001). For period 2, younger age at SCPC and greater daily caloric intake were associated with greater positive z (better growth; R(2) = 0.10, P = .002).
conclusionsAggressive nutritional support and earlier SCPC are modifiable factors associated with a favorable change in weight-for-age z-score.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.