Evidence map›Paper›PMID 21784297›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2011

Suicide attempts and nonsuicidal self-injury in the treatment of resistant depression in adolescents: findings from the TORDIA study.

Joan Rosenbaum Asarnow, Giovanna Porta, Anthony Spirito, Graham Emslie, Greg Clarke, Karen Dineen Wagner, Benedetto Vitiello, Martin Keller, Boris Birmaher, James McCracken and 3 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00018902 (Treatment of SSRI-Resistant Depression in Adolescents), which is not on this map. Cited by 249 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 19 pooled it
32.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00018902 phase2 / phase3completednot on this map

Treatment of SSRI-Resistant Depression in Adolescents (TORDIA)

TypeinterventionalSponsorUniversity of PittsburghRan2001 to 2007Enrolled334ConditionsDepressionArmsFluoxetine, Venlafaxine, Cognitive Behavioral Therapy (CBT), Citalopram
3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 19 syntheses or guidelines pooled it, 614 citations in OpenAlex.

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  12. Emotion dysregulation and non-suicidal self-injury: A systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2019
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  14. Psychological therapies for treatment-resistant depression in adults.The Cochrane database of systematic reviews · 2018
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189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Joan Rosenbaum AsarnowUniversity of California Los Angeles (UCLA), Department of Psychiatry, Los Angeles, CA 90095-6968, USA. jasarnow@mednet.ucla.edu
Giovanna Porta
Anthony Spirito
Graham Emslie
Greg Clarke
Karen Dineen Wagner
Benedetto Vitiello
Martin Keller
Boris Birmaher
James McCracken
Taryn Mayes
Michele Berk
David A Brent
University of Pittsburgh · USJohn Brown University · USThe University of Texas Southwestern Medical Center · USUniversity of California, Los Angeles · USKaiser Permanente · USNational Institutes of Health · USThe University of Texas Medical Branch at Galveston · USUCLA Health · US

Funding

Core--Research network developmentP30MH066371 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRENT, DAVID A. · 2002 to 2006
$8.2M
TREATMENT OF SSRI RESISTANT DEPRESSION IN ADOLESCENTSU01MH061835 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRENT, DAVID A. · 2000 to 2006
$3.3M
TREATMENT OF SSRI RESISTANT DEPRESSION IN ADOLESCENTSU01MH061869 · NIMH · KAISER FOUNDATION RESEARCH INSTITUTE · PI CLARKE, GREGORY N · 2000 to 2006
$2.8M
TREATMENT OF SSRI RESISTANT DEPRESSION IN ADOLESCENTSU01MH061856 · NIMH · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI WAGNER, KAREN D · 2000 to 2006
$1.9M
TREATMENT OF SSRI RESISTANT DEPRESSION IN ADOLESCENTSU01MH061958 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI EMSLIE, GRAHAM J. · 2000 to 2006
$1.8M
2/2-Evaluation of Family Focused Treatment for Childhood DepressionR01MH082856 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASARNOW, JOAN ROSENBAUM · 2009 to 2013
$1.8M
TREATMENT OF SSRI RESISTANT DEPRESSION IN ADOLESCENTSU01MH061864 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ASARNOW, JOAN ROSENBAUM · 2000 to 2006
$1.5M
TREATMENT OF SSRI-RESISTANT DEPRESSION IN ADOLESCENTSU01MH062014 · NIMH · BROWN UNIVERSITY · PI KELLER, MARTIN B · 2000 to 2006
$1.5M
NIMH NIH HHS MH61835NIMH NIH HHS MH61856NIMH NIH HHS MH61864NIMH NIH HHS MH61869NIMH NIH HHS MH61958NIMH NIH HHS MH62014NIMH NIH HHS MH66371NIMH NIH HHS P30 MH066371NIMH NIH HHS R01 MH082856NIMH NIH HHS U01 MH061835NIMH NIH HHS U01 MH061856NIMH NIH HHS U01 MH061864NIMH NIH HHS U01 MH061869NIMH NIH HHS U01 MH061958NIMH NIH HHS U01 MH062014
6 · The paper itself

Abstract

objectiveTo evaluate the clinical and prognostic significance of suicide attempts (SAs) and nonsuicidal self-injury (NSSI) in adolescents with treatment-resistant depression.

methodDepressed adolescents who did not improve with an adequate SSRI trial (N = 334) were randomized to a medication switch (SSRI or venlafaxine), with or without cognitive-behavioral therapy. NSSI and SAs were assessed at baseline and throughout the 24-week treatment period.

resultsOf the youths, 47.4% reported a history of self-injurious behavior at baseline: 23.9% NSSI alone, 14% NSSI+SAs, and 9.5% SAs alone. The 24-week incidence rates of SAs and NSSI were 7% and 11%, respectively; these rates were highest among youths with NSSI+SAs at baseline. NSSI history predicted both incident SAs (hazard ratio [HR]= 5.28, 95% confidence interval [CI] = 1.80-15.47, z = 3.04, p = .002) and incident NSSI (HR = 7.31, z = 4.19, 95% CI = 2.88-18.54, p < .001) through week 24, and was a stronger predictor of future attempts than a history of SAs (HR = 1.92, 95% CI = 0.81-4.52, z = 2.29, p = .13). In the most parsimonious model predicting time to incident SAs, baseline NSSI history and hopelessness were significant predictors, adjusting for treatment effects. Parallel analyses predicting time to incident NSSI through week 24 identified baseline NSSI history and physical and/or sexual abuse history as significant predictors.

conclusionsNSSI is a common problem among youths with treatment-resistant depression and is a significant predictor of future SAs and NSSI, underscoring the critical need for strategies that target the prevention of both NSSI and suicidal behavior. CLINICAL TRIAL REGISTRATION INFORMATION: Treatment of SSRI-Resistant Depression in Adolescents (TORDIA). URL: http://www.clinicaltrials.gov. Unique Identifier: NCT00018902.

Indexed as

Cognitive Behavioral TherapyDrug SubstitutionSuicide PreventionAdolescentAntidepressive AgentsChildCombined Modality TherapyCyclohexanolsDepressive DisorderFemaleHumansMaleProportional Hazards ModelsSelective Serotonin Reuptake InhibitorsSelf MutilationVenlafaxine HydrochlorideAntidepressive AgentsCyclohexanolsSelective Serotonin Reuptake InhibitorsVenlafaxine Hydrochloride

Identifiers

PMID21784297
PMCPMC3143365
OpenAlexW2018920598

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.