ArticleBone2011
Performance of the MRI-based virtual bone biopsy in the distal radius: serial reproducibility and reliability of structural and mechanical parameters in women representative of osteoporosis study populations.
Article in Bone, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- The Efficacy of Low-intensity Vibration to Improve Bone Health in Patients with End-stage Renal Disease Is Highly Dependent on Compliance and Muscle Response.Academic radiology · 2017Trial
- Osteoporosis in 10 years time: a glimpse into the future of osteoporosis.Therapeutic advances in musculoskeletal disease · 2022Article
- Bone Structure Analysis of the Radius Using Ultrahigh Field (7T) MRI: Relevance of Technical Parameters and Comparison with 3T MRI and Radiography.Diagnostics (Basel, Switzerland) · 2021Article
- Micro-Finite Element Analysis of the Proximal Femur on the Basis of High-Resolution Magnetic Resonance Images.Current osteoporosis reports · 2018Review
- The reproducibility of measuring trabecular bone parameters using a commercially available high-resolution magnetic resonance imaging approach: A pilot study.Bone reports · 2018Article
- Accuracy of MRI-based finite element assessment of distal tibia compared to mechanical testing.Bone · 2018Article
- Workflow and simulation of image-to-physical registration of holes inside spongy bone.International journal of computer assisted radiology and surgery · 2017Review
- MRI assessment of bone structure and microarchitecture.Journal of magnetic resonance imaging : JMRI · 2017Review
- Clinical Evaluation of Bone Strength and Fracture Risk.Current osteoporosis reports · 2017Review
- Trabecular bone characterization on the continuum of plates and rods using in vivo MR imaging and volumetric topological analysis.Physics in medicine and biology · 2016Article
- Measurement reproducibility of magnetic resonance imaging-based finite element analysis of proximal femur microarchitecture for in vivo assessment of bone strength.Magma (New York, N.Y.) · 2015Article
- Registration-based autofocusing technique for automatic correction of motion artifacts in time-series studies of high-resolution bone MRI.Journal of magnetic resonance imaging : JMRI · 2015Article
- Use of DXA-based technology for detection and assessment of risk of vertebral fracture in rheumatology practice.Current rheumatology reports · 2014Review
- Validation of quantitative magnetic resonance imaging-based apparent bone volume fraction in peri-articular tibial bone of cadaveric knees.BMC musculoskeletal disorders · 2014Article
- Assessment of trabecular bone yield and post-yield behavior from high-resolution MRI-based nonlinear finite element analysis at the distal radius of premenopausal and postmenopausal women susceptible to osteoporosis.Academic radiology · 2013Article
- Potential of in vivo MRI-based nonlinear finite-element analysis for the assessment of trabecular bone post-yield properties.Medical physics · 2013Article
- Cortical and trabecular bone structure analysis at the distal radius-prediction of biomechanical strength by DXA and MRI.Journal of bone and mineral metabolism · 2013Article
- Evaluation of trabecular microarchitecture in nonosteoporotic postmenopausal women with and without fracture.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Trabecular architecture and vertebral fragility in osteoporosis.Current osteoporosis reports · 2012Review
- Micro-MR imaging-based computational biomechanics demonstrates reduction in cortical and trabecular bone strength after renal transplantation.Radiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Serial reproducibility and reliability critically determine sensitivity to detect changes in response to intervention and provide a basis for sample size estimates. Here, we evaluated the performance of the MRI-based virtual bone biopsy in terms of 26 structural and mechanical parameters in the distal radius of 20 women in the age range of 50 to 75 years (mean=62.0 years, S.D.=8.1 years), representative of typical study populations in drug intervention trials and fracture studies. Subjects were examined three times at average intervals of 20.2 days (S.D.=14.5 days) by MRI at 1.5 T field strength at a voxel size of 137×137×410 μm(3). Methods involved prospective and retrospective 3D image registration and auto-focus motion correction. Analyses were performed from a central 5×5×5 mm(3) cuboid subvolume and trabecular volume consisting of a 13 mm axial slab encompassing the entire medullary cavity. Whole-volume axial stiffness and sub-regional Young's and shear moduli were computed by finite-element analysis. Whole-volume-derived aggregate mean coefficient of variation of all structural parameters was 4.4% (range 1.8% to 7.7%) and 4.0% for axial stiffness; corresponding data in the subvolume were 6.5% (range 1.6% to 13.0%) for structural, and 5.5% (range 4.6% to 6.5%) for mechanical parameters. Aggregate ICC was 0.976 (range 0.947 to 0.986) and 0.992 for whole-volume-derived structural parameters and axial stiffness, and 0.946 (range 0.752 to 0.991) and 0.974 (range 0.965 to 0.978) for subvolume-derived structural and mechanical parameters, respectively. The strongest predictors of whole-volume axial stiffness were BV/TV, junction density, skeleton density and Tb.N (R(2) 0.79-0.87). The same parameters were also highly predictive of sub-regional axial modulus (R(2) 0.88-0.91). The data suggest that the method is suited for longitudinal assessment of the response to therapy. The underlying technology is portable and should be compatible with all general-purpose MRI scanners, which is appealing considering the very large installed base of this modality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.