ArticleFish & shellfish immunology2011
Defining terminally differentiating B cell populations in rainbow trout immune tissues using the transcription factor XbpI.
Article in Fish & shellfish immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Immunological memory in a teleost fish: common carp IgMFrontiers in immunology · 2024Article
- A BCWD-Resistant line of rainbow trout is less sensitive to cortisol implant-induced changes in IgM response as compared to a susceptible (control) line.Developmental and comparative immunology · 2021Article
- Transient increase in abundance of B lineage but not myeloid-lineage cells in anterior kidney of sockeye salmon during return migration to the natal grounds.Fish & shellfish immunology · 2020Article
- Recent Advances on Phagocytic B Cells in Teleost Fish.Frontiers in immunology · 2020Review
- Network of microRNA-transcriptional factor-mRNA in cold response of turbot Scophthalmus maximus.Fish physiology and biochemistry · 2019Article
- Innate immune cell signatures in a BCWD-Resistant line of rainbow trout before and after in vivo challenge with Flavobacterium psychrophilum.Developmental and comparative immunology · 2019Article
- Melanomacrophages and melanomacrophage centres inCentral-European journal of immunology · 2019Review
- Long-Lived Plasma Cells Secrete High-Affinity Antibodies Responding to a T-Dependent Immunization in a Teleost Fish.Frontiers in immunology · 2019Article
- Specific humoral immunity inCentral-European journal of immunology · 2018Review
- A BCWD-resistant line of rainbow trout exhibits higher abundance of IgTDevelopmental and comparative immunology · 2017Article
- Modulation of immune response by organophosphorus pesticides: fishes as a potential model in immunotoxicology.Journal of immunology research · 2015Review
- Identification of B cells as a major site for cyprinid herpesvirus 3 latency.Journal of virology · 2014Article
- Expressed IgH μ and τ transcripts share diversity segment in ranched Thunnus orientalis.Developmental and comparative immunology · 2014Article
- Alternative splicing of the trout Pax5 gene and identification of novel B cell populations using Pax5 signatures.Developmental and comparative immunology · 2013Article
- Sockeye salmon retain immunoglobulin-secreting plasma cells throughout their spawning journey and post-spawning.Developmental and comparative immunology · 2013Article
- Influence of the cholinergic system on the immune response of teleost fishes: potential model in biomedical research.Clinical & developmental immunology · 2013Review
- Functional identification of dendritic cells in the teleost model, rainbow trout (Oncorhynchus mykiss).PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The nature of antibody-secreting cells in the rainbow trout is poorly defined. Here we describe a flow cytometric approach to help differentiate between four major trout B cell subsets present during terminal B cell differentiation: resting B cells, activated B cells, plasmablasts, and plasma cells. To aid in the identification of B cell subsets, the LPS-inducible transcription factor XbpI-S was used as a marker. An antibody specific to the stable form of inducible transcription factor X-box protein I (XbpI) was generated, which detects XbpI-S protein expression for species within the Oncorhyncus genus, including rainbow trout. Combinatorial expression patterns, or B cell signatures, were established using antibodies to XbpI-S, Pax5, and IgM in combination with a proliferation marker. We show that XbpI-S induction in trout splenic B cells increases throughout a 10-day in vitro LPS-induction period and that increased XbpI-S expression correlates with increased HCmu expression in the cell. PBLs displayed a lower level of XbpI-S induction during this incubation period, compared to spleen. We conclude that trout B cells follow a highly conserved B cell activation pathway, albeit slower than what has been observed in mammalian species. The use of XbpI-S as an activation marker for trout humoral immune activation promises to be useful for future in vivo studies, and can be applied to a broad range of teleost species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.