Evidence map›Paper›PMID 21784145›Full record

Trial reportBrain, behavior, and immunity2011

Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial.

Janice K Kiecolt-Glaser, Martha A Belury, Rebecca Andridge, William B Malarkey, Ronald Glaser

4 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Brain, behavior, and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 151 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed, 17 pooled it
13.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00519779 phase2completednot on this map

Academic Stress and Proinflammatory Cytokines: Omega-3 Intervention

TypeinterventionalSponsorNational Center for Complementary and Integrative Health (NCCIH)Ran2007 to 2010Enrolled68ConditionsStress-related Changes in InflammationArmsomega-3 supplementation, Oral omega-3 fish oil placebo
NCT02908932 nacompletednot on this mapstarted 2016, after this paper: background citation

Ranger Resilience and Improved Performance on Phospholipid Bound Omega-3's

TypeinterventionalSponsorMedical University of South CarolinaRan2016 to 2018Enrolled555ConditionsNutrition, Fatty Acids, Omega-3, Cognition, Resilience, PsychologicalArmsPhospholipid-bound omega-3 supplement, Placebo supplement
NCT04844034 naunknown statusnot on this mapstarted 2022, after this paper: background citation

The Effects of a High Eicosapentaenoic Acid Multinutrient Supplement on Measures of Stress, Anxiety and Depression in Young Adults: a Randomised, Double-blind, Placebo-controlled Trial.

TypeinterventionalSponsorUniversity of RoehamptonRan2022 to 2023Enrolled94ConditionsAnxiety, DepressionArmsHigh-EPA multinutrient supplement., Placebo
NCT06995586 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.

TypeinterventionalSponsorNicosia General HospitalRan2026 to 2028Enrolled108ConditionsCardio-pulmonary Bypass, Cardiovascular Diseases, Omega-3 Polyunsaturated Fatty Acids, Omega-3 SupplementationArmsVitamin C, Omega 3 PUFA (EPO/DHA), Lignin, Lactulose
3 · Its place in the literature

Who cites it

151 citing papers in PubMed, 17 syntheses or guidelines pooled it, 326 citations in OpenAlex.

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91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Janice K Kiecolt-GlaserInstitute for Behavioral Medicine Research, Ohio State University College of Medicine, OH 43210, USA. Janice.Kiecolt-Glaser@osumc.edu
Martha A Belury
Rebecca Andridge
William B Malarkey
Ronald Glaser
The Ohio State University · USInstitute for Behavioral Medicine · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
University of Iowa Clinical and Translational Science Program (TL1)UL1RR025755 · NCRR · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2008 to 2011
$26.3M
The Ohio State University Center for Clinical and Translational Science (UL1)UL1TR000090 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2012 to 2013
$7.9M
Stress and Proinflammatory Cytokines: Omega-3 InterventionR21AT003912 · NCCIH · OHIO STATE UNIVERSITY · PI KIECOLT-GLASER, JANICE · 2007 to 2009
$623k
NCATS NIH HHS UL1 TR000090NCCIH NIH HHS AT003912NCCIH NIH HHS R21 AT003912NCI NIH HHS CA16058NCI NIH HHS P30 CA016058NCRR NIH HHS UL1 RR025755NCRR NIH HHS UL1RR025755
6 · The paper itself

Abstract

Observational studies have linked lower omega-3 (n-3) polyunsaturated fatty acids (PUFAs) and higher omega-6 (n-6) PUFAs with inflammation and depression, but randomized controlled trial (RCT) data have been mixed. To determine whether n-3 decreases proinflammatory cytokine production and depressive and anxiety symptoms in healthy young adults, this parallel group, placebo-controlled, double-blind 12-week RCT compared n-3 supplementation with placebo. The participants, 68 medical students, provided serial blood samples during lower-stress periods as well as on days before an exam. The students received either n-3 (2.5 g/d, 2085 mg eicosapentaenoic acid and 348 mg docosahexanoic acid) or placebo capsules that mirrored the proportions of fatty acids in the typical American diet. Compared to controls, those students who received n-3 showed a 14% decrease in lipopolysaccharide (LPS) stimulated interleukin 6 (IL-6) production and a 20% reduction in anxiety symptoms, without significant change in depressive symptoms. Individuals differ in absorption and metabolism of n-3 PUFA supplements, as well as in adherence; accordingly, planned secondary analyses that used the plasma n-6:n-3 ratio in place of treatment group showed that decreasing n-6:n-3 ratios led to lower anxiety and reductions in stimulated IL-6 and tumor necrosis factor alpha (TNF-α) production, as well as marginal differences in serum TNF-α. These data suggest that n-3 supplementation can reduce inflammation and anxiety even among healthy young adults. The reduction in anxiety symptoms associated with n-3 supplementation provides the first evidence that n-3 may have potential anxiolytic benefits for individuals without an anxiety disorder diagnosis. ClinicalTrials.gov identifier: NCT00519779.

Indexed as

Dietary SupplementsAdultAffectAnxietyCytokinesDepressionDietDouble-Blind MethodExerciseFatty AcidsFatty Acids, Omega-3FemaleHealth BehaviorHumansInflammationMaleCytokinesFatty AcidsFatty Acids, Omega-3

Identifiers

PMID21784145
PMCPMC3191260
OpenAlexW2140758044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.