ArticleInternational journal for parasitology2011
Schistosoma mansoni population structure and persistence after praziquantel treatment in two villages of Bahia, Brazil.
Article in International journal for parasitology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 57 citations in OpenAlex.
- Extensive parasite transmission and variation in a functional receptor associated with drug resistance in endemicScience advances · 2026Article
- Genetic analysis of Schistosoma mansoni in a low-transmission area in Brazil suggests population sharing between wild-hosts and humans and geographical isolation.PLoS neglected tropical diseases · 2025Article
- Evidence for local transmission and maintenance of schistosomiasis in an urban neighbourhood in Northeast Brazil.Transboundary and emerging diseases · 2022Article
- Integrating genomic and epidemiologic data to accelerate progress toward schistosomiasis elimination.eLife · 2022Review
- Genome-wide analysis of Schistosoma mansoni reveals limited population structure and possible praziquantel drug selection pressure within Ugandan hot-spot communities.PLoS neglected tropical diseases · 2022Article
- Whole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration.Nature communications · 2021Article
- Exploring the genetic structure of Parastrigea diovadena Dubois and Macko, 1972 (Digenea: Strigeidae), an endoparasite of the white ibis, Eudocimus albus, from the Neotropical region of Mexico.Parasitology research · 2021Article
- Genetic evidence for the role of non-human primates as reservoir hosts for human schistosomiasis.PLoS neglected tropical diseases · 2020Article
- Parasite Population Genetic Contributions to the Schistosomiasis Consortium for Operational Research and Evaluation within Sub-Saharan Africa.The American journal of tropical medicine and hygiene · 2020Review
- Does Intensive Treatment Select for Praziquantel Resistance in High-Transmission Settings? Parasitological Trends and Treatment Efficacy Within a Cluster-Randomized Trial.Open forum infectious diseases · 2020Article
- The changing profile of schistosomiasis in a changing urban landscape.International journal for parasitology · 2020Article
- Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda.Parasites & vectors · 2019Article
- Population Structure and Dynamics of Helminthic Infection: Schistosomiasis.Microbiology spectrum · 2019Review
- The effect of sample size on estimates of genetic differentiation and effective population size for Schistosoma mansoni populations.International journal for parasitology · 2018Article
- (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach.Trends in parasitology · 2017Review
- Whole Genome Amplification and Reduced-Representation Genome Sequencing of Schistosoma japonicum Miracidia.PLoS neglected tropical diseases · 2017Article
- Repeated praziquantel treatments remodel the genetic and spatial landscape of schistosomiasis risk and transmission.International journal for parasitology · 2016Article
- Reconstructing Colonization Dynamics of the Human Parasite Schistosoma mansoni following Anthropogenic Environmental Changes in Northwest Senegal.PLoS neglected tropical diseases · 2015Article
- Can human schistosomiasis mansoni control be sustained in high-risk transmission foci in Egypt?Parasites & vectors · 2015Article
- The relative contribution of immigration or local increase for persistence of urban schistosomiasis in Salvador, Bahia, Brazil.PLoS neglected tropical diseases · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Praziquantel has been used to treat schistosome infections since 1979 and currently is the only chemotherapeutic agent in production for this purpose, raising concerns about the potential for the emergence of drug resistance. In practice, 10-20% of infected patients will continue to excrete eggs after treatment. It is not understood to what degree this represents selection of a resistant population or incomplete elimination due to the presence of immature worms at the time of treatment. We used a population genetics approach to test whether or not persistent Schistosomamansoni parasites were drawn from the same population as susceptible parasites. In this study, stool samples were collected from 96% of individuals in two small Brazilian communities (populations 482 and 367) and examined for S.mansoni eggs. The combined prevalence of S.mansoni infections in the villages was 41%. Total egg DNA was extracted from each sample and was genotyped at 15 microsatellite markers. Day-to-day variation of the infrapopulation from an individual human host was low (median differentiation using Jost's D=0.010), so that a single stool was representative of the genotypes present in stool eggs, at least in the short term. Average pairwise analysis of D among all pre-treatment infrapopulations suggested moderate differentiation (mean D=0.082 and 0.122 for the two villages), whereas the pre-treatment component population differentiation between the two communities was 0.047. The differentiation of the component population remaining after treatment from the fully susceptible component population was low (mean D=0.007 and 0.020 for the two villages), suggesting that the persistent parasites were not selected by praziquantel treatment. We will continue to follow these communities for evidence of selection or changes in population structure.
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