ReviewPeptides2011
Stress-related alterations of acyl and desacyl ghrelin circulating levels: mechanisms and functional implications.
Review in Peptides, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Ghrelin in Depression: A Promising Therapeutic Target.Molecular neurobiology · 2025Review
- Satiety Hormone LEAP2 After Low-Calorie Diet With/Without Endobarrier Insertion in Obesity and Type 2 Diabetes Mellitus.Journal of the Endocrine Society · 2024Article
- Potentials of Acetylcholinesterase and Butyrylcholinesterase Alterations in On-Pump Coronary Artery Bypass Surgery in Postoperative Delirium: An Observational Trial.Journal of clinical medicine · 2023Article
- Perceived stress and depressive symptoms among Chinese college students: A moderated mediation model of biorhythm and ego resilience.Frontiers in public health · 2022Article
- Beneficial Potential ofFrontiers in pharmacology · 2021Article
- Vulnerability to psychological stress-induced anorexia in female mice depends on blockade of ghrelin signal in nucleus tractus solitarius.British journal of pharmacology · 2020Article
- Diet, Stress and Mental Health.Nutrients · 2020Review
- Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity.Molecular metabolism · 2019Article
- Gut-Brain Neuroendocrine Signaling Under Conditions of Stress-Focus on Food Intake-Regulatory Mediators.Frontiers in endocrinology · 2018Review
- Corticotropin-releasing factor overexpression in mice abrogates sex differences in body weight, visceral fat, and food intake response to a fast and alters levels of feeding regulatory hormones.Biology of sex differences · 2017Article
- Neonatal overfeeding disrupts pituitary ghrelin signalling in female rats long-term; Implications for the stress response.PloS one · 2017Article
- Physiological roles for butyrylcholinesterase: A BChE-ghrelin axis.Chemico-biological interactions · 2016Review
- Circulating ghrelin level is higher in HNF1A-MODY and GCK-MODY than in polygenic forms of diabetes mellitus.Endocrine · 2015Article
- Inverse association of des-acyl ghrelin with worksite blood pressure in overweight/obese male workers.Environmental health and preventive medicine · 2015Article
- Specific appetite, energetic and metabolomics responses to fat overfeeding in resistant-to-bodyweight-gain constitutional thinness.Nutrition & diabetes · 2014Article
- Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications.Cell metabolism · 2014Review
- Orexigenic response to tail pinch: role of brain NPY(1) and corticotropin releasing factor receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Ghrelin and ghrelin receptor modulation of psychostimulant action.Frontiers in neuroscience · 2013Review
- Taking two to tango: a role for ghrelin receptor heterodimerization in stress and reward.Frontiers in neuroscience · 2013Review
- Cortisol and ghrelin concentrations following a cold pressor stress test in overweight individuals with and without night eating.International journal of obesity (2005) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Ghrelin is the only known peripherally produced and centrally acting peptide hormone that stimulates food intake and digestive functions. Ghrelin circulates as acylated and desacylated forms and recently the acylating enzyme, ghrelin-O-acyltransferase (GOAT) and the de-acylating enzyme, thioesterase 1/lysophospholipase 1 have been identified adding new layers of complexity to the regulation of ghrelin. Stress is known to alter gastrointestinal motility and food intake and was recently shown to modify circulating ghrelin and GOAT levels with differential responses related to the type of stressors including a reduction induced by physical stressors (abdominal surgery and immunological/endotoxin injection, exercise) and elevation by metabolic (cold exposure, acute fasting and caloric restriction) and psychological stressors. However, the pathways underlying the alterations of ghrelin under these various stress conditions are still largely to be defined and may relate to stress-associated autonomic changes. There is evidence that alterations of circulating ghrelin may contribute to the neuroendocrine and behavioral responses along with sustaining the energetic requirement needed upon repeated exposure to stressors. A better understanding of these mechanisms will allow targeting components of ghrelin signaling that may improve food intake and gastric motility alterations induced by stress.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.