Evidence map›Paper›PMID 21782511›Full record

ReviewTrends in immunology2011

Neutrophil clearance: when the party is over, clean-up begins.

Donna L Bratton, Peter M Henson

Abstract readReview
In one paragraph

Review in Trends in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 189 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
189citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

189 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Innate immunity: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Frontiers in immunology · 2026
    Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Neutrophil death-more than meets the eye.Experimental hematology · 2025
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. iScience · 2025
    Article

129 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Donna L BrattonNational Jewish Health, 1400 Jackson Street, Room A540, Denver, CO 80206, USA. brattond@njhealth.org
Peter M Henson

Funding

TRANSLOCATION AND TRANSCELLULAR BIOSYNTHESISP01HL034303 · NHLBI · NATIONAL JEWISH HEALTH · PI BARKLEY, ROBERT · 1985 to 2015
$25.0M
Regulation of Pulmonary InflammationR01HL081151 · NHLBI · NATIONAL JEWISH HEALTH · PI HENSON, PETER M · 2005 to 2012
$3.5M
REGULATION OF INFLAMMATION BY PULMONARY COLLECTINSR01HL068864 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI HENSON, PETER M · 2002 to 2012
$3.3M
Uptake of apoptotic cellsR01GM061031 · NIGMS · NATIONAL JEWISH HEALTH · PI HENSON, PETER M · 2001 to 2009
$3.0M
NHLBI NIH HHS HL34303NHLBI NIH HHS HL68864NHLBI NIH HHS HL81151NHLBI NIH HHS P01 HL034303NHLBI NIH HHS R01 HL068864NHLBI NIH HHS R01 HL081151NIGMS NIH HHS GM61031NIGMS NIH HHS R01 GM061031
6 · The paper itself

Abstract

Maintenance of circulating, functional neutrophils and their robust recruitment to tissues in response to injury and/or microbial infection are crucial for host defense. Equally important, although less well understood, are the processes for removal of these short-lived cells. Here, we review recent findings of novel neutrophil characteristics that determine removal. These neutrophil-derived signals, in turn, can shape the responses of other cells and surrounding tissues and promote a return to homeostasis. If not removed, dying neutrophils disintegrate and release phlogistic cargo that can further contribute to ongoing inflammation, tissue destruction, or autoimmunity.

Indexed as

CytophagocytosisImmunotherapyAnimalsApoptosisCell CommunicationHumansInflammationMacrophagesNeutrophilsPulmonary Disease, Chronic ObstructiveReperfusion InjurySignal Transduction

Identifiers

PMID21782511
PMCPMC3151332

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.