ArticleCurrent biology : CB2011
Adaptive introgression of anticoagulant rodent poison resistance by hybridization between old world mice.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
153 citing papers in PubMed, 1 synthesis or guideline pooled it, 367 citations in OpenAlex.
- Independent evolution toward larger body size in the distinctive Faroe Island mice.G3 (Bethesda, Md.) · 2021Pooled it
- Genetics and genomics of hybridization.Nature reviews. Genetics · 2026Review
- A comparative evaluation of the efficacy of traps and rodenticide baits in field studies with house mice (Mus musculus).Scientific reports · 2026Article
- Weak but Repeated Patterns of Co-Introgression of Nuclear OXPHOS Genes and Mitochondrial DNA in Iberian Wall Lizards.Genome biology and evolution · 2026Article
- Distribution and frequency of Vkorc1 polymorphisms in house mice and Norway rats in the northeastern United States.Pest management science · 2026Article
- Genetic parallelism underpins convergent mimicry coloration in Lepidoptera across 120 million years of evolution.PLoS biology · 2026Article
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- Spatial prediction of animal plague risk in Qinghai Province, China using MaxEnt modeling: implications for targeted control.Frontiers in veterinary science · 2026Article
- Experimentally Testing the Hypothesis That Hybrid Fitness Can Increase Evolutionarily: An Example in Spadefoot Toads.Ecology and evolution · 2025Article
- A colorful legacy of hybridization in wood-warblers includes frequent sharing of carotenoid genes among species and genera.PLoS biology · 2025Article
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- Replicate geographic transects across a hybrid zone reveal parallelism and differences in the genetic architecture of reproductive isolation.Evolution letters · 2025Article
- Speciation in the Peninsular Indian Flying Lizard (Draco dussumieri) Follows Climatic Transition and Not Physical Barriers.Molecular ecology · 2025Article
- Trans-Atlantic Dispersal and Introgression Explain Holarctic Disjunct Distributions in Vanessa Butterflies.Molecular ecology · 2025Article
- Adaptive Introgression as an Evolutionary Force: A Meta-Analysis of Knowledge Trends.Evolutionary applications · 2025Article
- Intact, recombinant, and spliced forms of endogenous mouse mammary tumor viruses in inbred and wild mice.Journal of virology · 2025Article
- Widespread anticoagulant resistance in house mice (Mus musculus musculus) linked to the Tyr139Phe mutation in the Czech Republic.Scientific reports · 2025Article
- Article
- Widespread Adaptive Introgression of Major Histocompatibility Complex Genes across Vertebrate Hybrid Zones.Molecular biology and evolution · 2024Article
- Swordtail fish hybrids reveal that genome evolution is surprisingly predictable after initial hybridization.PLoS biology · 2024Article
93 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Polymorphisms in the vitamin K 2,3-epoxide reductase subcomponent 1 (vkorc1) of house mice (Mus musculus domesticus) can cause resistance to anticoagulant rodenticides such as warfarin [1-3]. Here we show that resistant house mice can also originate from selection on vkorc1 polymorphisms acquired from the Algerian mouse (M. spretus) through introgressive hybridization. We report on a polymorphic introgressed genomic region in European M. m. domesticus that stems from M. spretus, spans >10 Mb on chromosome 7, and includes the molecular target of anticoagulants vkorc1 [1-4]. We show that in the laboratory, the homozygous complete vkorc1 allele of M. spretus confers resistance when introgressed into M. m. domesticus. Consistent with selection on the introgressed allele after the introduction of rodenticides in the 1950s, we found signatures of selection in patterns of variation in M. m. domesticus. Furthermore, we detected adaptive protein evolution of vkorc1 in M. spretus (Ka/Ks = 1.54-1.93) resulting in radical amino acid substitutions that apparently cause anticoagulant tolerance in M. spretus as a pleiotropic effect. Thus, positive selection produced an adaptive, divergent, and pleiotropic vkorc1 allele in the donor species, M. spretus, which crossed a species barrier and produced an adaptive polymorphic trait in the recipient species, M. m. domesticus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.