ArticleCurrent biology : CB2011
A new molecular logic for BMP-mediated dorsoventral patterning in the leech Helobdella.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 68 citations in OpenAlex.
- Developmental system drift in dorsoventral patterning is linked to transitions to autonomous development in Annelida.Nature communications · 2026Article
- Brachiopod genome unveils the evolution of BMP signalling in bilaterian body patterning.Nature communications · 2026Article
- Evidence of autonomous neural specification for both brain and ventral nerve cord tissue in Annelida.bioRxiv : the preprint server for biology · 2026Article
- Early nervous system development in the chaetognathFrontiers in cell and developmental biology · 2026Article
- Hedgehog Signaling during Gut Formation in the Freshwater Leech, Helobdella austinensis.Cells, tissues, organs · 2025Article
- Highly conserved and extremely evolvable: BMP signalling in secondary axis patterning of Cnidaria and Bilateria.Development genes and evolution · 2024Review
- Capitella teleta gets left out: possible evolutionary shift causes loss of left tissues rather than increased neural tissue from dominant-negative BMPR1.Neural development · 2024Article
- Genome-wide investigation of the TGF-β superfamily in scallops.BMC genomics · 2024Article
- DNA Conserved in Diverse Animals Since the Precambrian Controls Genes for Embryonic Development.Molecular biology and evolution · 2023Article
- Head transcriptome profiling of glossiphoniid leech (Open biology · 2022Article
- Molluskan Dorsal-Ventral Patterning Relying on BMP2/4 and Chordin Provides Insights into Spiralian Development and Evolution.Molecular biology and evolution · 2022Article
- Article
- Functional evidence that Activin/Nodal signaling is required for establishing the dorsal-ventral axis in the annelidDevelopment (Cambridge, England) · 2020Article
- Apcdd1 is a dual BMP/Wnt inhibitor in the developing nervous system and skin.Developmental biology · 2020Article
- BMP signaling plays a role in anterior-neural/head development, but not organizer activity, in the gastropod Crepidula fornicata.Developmental biology · 2020Article
- Spatiotemporal Expression of Anticoagulation FactorInternational journal of molecular sciences · 2019Article
- Animal regeneration: ancestral character or evolutionary novelty?EMBO reports · 2017Review
- Regulation of dorso-ventral polarity by the nerve cord during annelid regeneration: A review of experimental evidence.Regeneration (Oxford, England) · 2017Review
- Expression patterns indicate that BMP2/4 and Chordin, not BMP5-8 and Gremlin, mediate dorsal-ventral patterning in the mollusk Crassostrea gigas.Development genes and evolution · 2017Article
- Axis Patterning by BMPs: Cnidarian Network Reveals Evolutionary Constraints.Cell reports · 2015Article
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Abstract
Bone morphogenetic protein (BMP) signaling is broadly implicated in dorsoventral (DV) patterning of bilaterally symmetric animals [1-3], and its role in axial patterning apparently predates the birth of Bilateria [4-7]. In fly and vertebrate embryos, BMPs and their antagonists (primarily Sog/chordin) diffuse and interact to generate signaling gradients that pattern fields of cells [8-10]. Work in other species reveals diversity in essential facets of this ancient patterning process, however. Here, we report that BMP signaling patterns the DV axis of segmental ectoderm in the leech Helobdella, a clitellate annelid (superphylum Lophotrochozoa) featuring stereotyped developmental cell lineages, but the detailed mechanisms of DV patterning in Helobdella differ markedly from fly and vertebrates. In Helobdella, BMP2/4s are expressed broadly, rather than in dorsal territory, whereas a dorsally expressed BMP5-8 specifies dorsal fate by short-range signaling. A BMP antagonist, gremlin, is upregulated by BMP5-8 in dorsolateral, rather than ventral territory, and yet the BMP-antagonizing activity of gremlin is required for normal ventral cell fates. Gremlin promotes ventral fates without disrupting dorsal fates by selectively inhibiting BMP2/4s, not BMP5-8. Thus, DV patterning in the development of the leech revealed unexpected evolutionary plasticity of the conserved BMP patterning system, presumably reflecting its adaptation to different modes of embryogenesis.
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