Evidence map›Paper›PMID 21782417›Full record

ArticleCurrent opinion in structural biology2011

The power of correlative microscopy: multi-modal, multi-scale, multi-dimensional.

Jeffrey Caplan, Marc Niethammer, Russell M Taylor, Kirk J Czymmek

Open access · greenAbstract read
In one paragraph

Article in Current opinion in structural biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
9.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 162 citations in OpenAlex.

  1. Review
  2. Teliosporogenesis of the Peanut Smut FungusPlants (Basel, Switzerland) · 2026
    Article
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  4. Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Correlative Fluorescent Scanning Probe Nanotomography Used to Study the Intracellular Distribution of Doxorubicin in MCF-7 Human Breast Adenocarcinoma Cells.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2023
    Article
  10. Article
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  12. Light and focused ion beam microscopy workflow for resin-embedded tissues.Frontiers in cell and developmental biology · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Article
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  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Jeffrey CaplanDelaware Biotechnology Institute Bio-Imaging Center, University of Delaware, Newark, DE 19711, United States.
Marc Niethammer
Russell M Taylor
Kirk J Czymmek
Biotechnology Institute · USImaging Center · USUniversity of Delaware · USUniversity of North Carolina at Chapel Hill · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026
$67.2M
VOLUMETRIC BREAST DENSITY ESTIMATION USING BREAST SURFACE RECONSTRUCTEDP20RR016472 · NCRR · UNIVERSITY OF DELAWARE · PI STANHOPE, STEVEN J. · 2001 to 2011
$37.6M
VIEW: VISUALIZATION IMPROMPTU EVALUATION WORKBENCHP41RR002170 · NCRR · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI SUPERFINE, RICHARD · 1989 to 2002
$3.8M
NCRR NIH HHS 5-P41-RR02170NCRR NIH HHS P20 RR016472NCRR NIH HHS P41 RR002170NIGMS NIH HHS P20 GM103446
6 · The paper itself

Abstract

Correlative microscopy is a sophisticated approach that combines the capabilities of typically separate, but powerful microscopy platforms: often including, but not limited, to conventional light, confocal and super-resolution microscopy, atomic force microscopy, transmission and scanning electron microscopy, magnetic resonance imaging and micro/nano CT (computed tomography). When targeting rare or specific events within large populations or tissues, correlative microscopy is increasingly being recognized as the method of choice. Furthermore, this multi-modal assimilation of technologies provides complementary and often unique information, such as internal and external spatial, structural, biochemical and biophysical details from the same targeted sample. The development of a continuous stream of cutting-edge applications, probes, preparation methodologies, hardware and software developments will enable realization of the full potential of correlative microscopy.

Indexed as

AnimalsCellsElectron Microscope TomographyFluorescenceHumansImage Processing, Computer-AssistedMicroscopyMolecular ProbesOxidants, PhotochemicalProtein Interaction MappingSoftwareTissue PreservationMolecular ProbesOxidants, Photochemical

Identifiers

PMID21782417
PMCPMC3189301
OpenAlexW2134611117

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.