Trial reportNutrition, metabolism, and cardiovascular diseases : NMCD2012
Vitamin E differentially affects short term exercise induced changes in oxidative stress, lipids, and inflammatory markers.
Trial report in Nutrition, metabolism, and cardiovascular diseases : NMCD, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Strenuous Exercise and Quercetin Supplementation Differentially Alter Lipid Metabolism in C57BL/6J Mice.Journal of lipid and atherosclerosis · 2026Article
- Exercise and Endothelial Function: Insights from a Redox Perspective.Current atherosclerosis reports · 2026Review
- Commemorating Dr. Sampath (Sam) Parthasarathy for his Exceptional Research in Biochemistry and Lipidology in Health and Diseaseand Legacy as a Superb Mentor and Scientist.Cell biochemistry and biophysics · 2026Article
- Harnessing Statistical and Machine Learning Approaches to Analyze Oxidized LDL in Clinical Research.Cell biochemistry and biophysics · 2025Review
- Exploring the Relationship between Micronutrients and Athletic Performance: A Comprehensive Scientific Systematic Review of the Literature in Sports Medicine.Sports (Basel, Switzerland) · 2023Review
- Influence of vitamin C supplementation on oxidative stress and neutrophil inflammatory response in acute and regular exercise.Oxidative medicine and cellular longevity · 2015Article
- Accumulation of hydroxyl lipids and 4-hydroxy-2-hexenal in live fish infected with fish diseases.Lipids · 2014Article
- Quercetin intake with exercise modulates lipoprotein metabolism and reduces atherosclerosis plaque formation.Journal of the International Society of Sports Nutrition · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimPhysical activity or exercise is a proven deterrent of cardiovascular diseases. The purpose of this study was to examine whether vitamin E supplementation interfere with the potential benefits of exercise. METHODS AND
resultsA total of 455 apparently healthy men and women were recruited, for a 2-month aerobic/cardiovascular exercise program. Subjects were randomly assigned for soft gel vitamin E or placebo (800 IU), and required to give blood at 0, 2, 4 and 8 weeks of exercise. Levels of lipid and markers of oxidative stress and inflammation were measured along with the VO2 and duration time spent on treadmill. Statistical analysis did not show significant changes in the levels of lipids and markers of oxidative stress and inflammation. Favorable trends among both of the randomization groups were observed in lipids, and some of the oxidative stress and inflammatory markers. This study also established several interesting correlations between VO2, and lipids on one hand and markers of oxidation and inflammation on the other hand. Reduction in LDL levels positively associated with increased levels of MCP-1 (P < 0.008) among placebo group, and also decreased hCRP levels strongly correlated with the increases in VO2 (P < 0.0004) among the placebo, and vitamin E subjects (P < 0.01).
conclusionsExercise training induces oxidative stress might be instrumental in favorable lipid reduction and markers of oxidative stress and inflammation. However interestingly, vitamin E didn't demonstrate favorable effects on the level of oxidative stress and inflammation associated with exercise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.