Evidence map›Paper›PMID 21782155›Full record

ReviewBrain research2011

Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior.

Antoine G Almonte, J David Sweatt

Open access · greenAbstract readReview
In one paragraph

Review in Brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Proteases: Role in Various Human Diseases.Current pharmaceutical biotechnology · 2025
    Review
  8. TDP-43-mediated amyotrophic lateral sclerosis: new/hidden insights fromFrontiers in cell and developmental biology · 2025
    Article
  9. Screening ofHeliyon · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Selected βMolecules (Basel, Switzerland) · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Antoine G AlmonteDepartment of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
J David Sweatt
University of Alabama at Birmingham · US

Funding

Alabama Neuroscience Blueprint Core CenterP30NS057098 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROTH, KEVIN A · 2006 to 2010
$9.5M
Biochemical Mechanisms of Neural PlasticityR01MH057014 · NIMH · VANDERBILT UNIVERSITY · PI WINDER, DANNY G. · 1996 to 2019
$9.3M
Trophic Interactions of Nerve and MuscleR01AG031722 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SWEATT, JOHN DAVID · 2007 to 2011
$1.6M
NIA NIH HHS AG031722NIA NIH HHS R01 AG031722NIMH NIH HHS MH57014NIMH NIH HHS R01 MH057014NINDS NIH HHS NS 057098NINDS NIH HHS P30 NS057098
6 · The paper itself

Abstract

Serine proteases, serine protease inhibitors, and protease-activated receptors have been intensively investigated in the periphery and their roles in a wide range of processes-coagulation, inflammation, and digestion, for example-have been well characterized (see Coughlin, 2000; Macfarlane et al., 2001; Molinari et al., 2003; Wang et al., 2008; Di Cera, 2009 for reviews). A growing number of studies demonstrate that these protein systems are widely expressed in many cell types and regions in mammalian brains. Accumulating lines of evidence suggest that the brain has co-opted the activities of these interesting proteins to regulate various processes underlying synaptic activity and behavior. In this review, we discuss emerging roles for serine proteases in the regulation of mechanisms underlying synaptic plasticity and memory formation.

Indexed as

AnimalsAstrocytesBehaviorBehavior, AnimalHumansNeuronsReceptors, Proteinase-ActivatedSerine ProteasesSerine Proteinase InhibitorsSignal TransductionSynapsesReceptors, Proteinase-ActivatedSerine ProteasesSerine Proteinase Inhibitors

Identifiers

PMID21782155
PMCPMC3148282
OpenAlexW2040222971

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.