ReviewAdvances in chronic kidney disease2011
Glomerular proteinuria: a complex interplay between unique players.
Review in Advances in chronic kidney disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Biofabrication of a Filtration Barrier by Integrating Electrospun Membranes and Flow in a Glomerular Co-Culture.Advanced healthcare materials · 2025Article
- Histopathology of Diabetic Nephropathy: Beyond Glomerular Basement Membrane Thickening.Cureus · 2025Review
- Glycosylation-Related Genes and Prognostic Signatures in Diabetic Nephropathy.International journal of general medicine · 2025Article
- Is It Time for a Requiem for Creatine Supplementation-Induced Kidney Failure? A Narrative Review.Nutrients · 2023Review
- Albumin is an interface between blood plasma and cell membrane, and not just a sponge.Clinical kidney journal · 2022Article
- Biomimetic models of the glomerulus.Nature reviews. Nephrology · 2022Review
- Development of Biomarkers and Molecular Therapy Based on Inflammatory Genes in Diabetic Nephropathy.International journal of molecular sciences · 2021Review
- Distinct effects of ANGPT2 on gene expression of glomerular podocytes and mesangial cells.American journal of translational research · 2021Article
- Chrysin ameliorates podocyte injury and slit diaphragm protein loss via inhibition of the PERK-eIF2α-ATF-CHOP pathway in diabetic mice.Acta pharmacologica Sinica · 2017Article
- Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury.Molecular and cellular biology · 2016Article
- The Prediction of Key Cytoskeleton Components Involved in Glomerular Diseases Based on a Protein-Protein Interaction Network.PloS one · 2016Article
- Endothelin-1 and the kidney: new perspectives and recent findings.Current opinion in nephrology and hypertension · 2016Review
- Article
- The Role of Endothelin System in Renal Structure and Function during the Postnatal Development of the Rat Kidney.PloS one · 2016Article
- Sickle cell disease: renal manifestations and mechanisms.Nature reviews. Nephrology · 2015Review
- Proteinuria is associated with neurocognitive impairment in antiretroviral therapy treated HIV-infected individuals.Journal of acquired immune deficiency syndromes (1999) · 2014Observational
- Chronic kidney disease: a new look at pathogenetic mechanisms and treatment options.Pediatric nephrology (Berlin, Germany) · 2014Review
- Membrane trafficking in podocyte health and disease.Pediatric nephrology (Berlin, Germany) · 2013Review
- Podocyte-specific knockout of myosin 1e disrupts glomerular filtration.American journal of physiology. Renal physiology · 2012Article
- The glomerular filtration barrier: components and crosstalk.International journal of nephrology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Protein leak in the urine is a harbinger of disruption of the glomerular filtration barrier. It also correlates with disease progression and development of ESRD. At present, therapies are aimed at decreasing proteinuria to decrease further damage to the filter and as a marker of remission. Understanding the mechanism of molecular events that lead to protein leak is vital to developing new therapeutic interventions. There has been tremendous progress over the last decade in identifying gene defects which result in hereditary proteinuric defects. This has led to identifying pathways by which these genes regulate the structure and function of the components of the filtration barrier, namely the podocytes, mesangial cells, endothelial cells, and the basement membrane. Using gene knockout mouse models, a role of tubular cells in regulating proteinuria is also emerging. In this review, we have attempted to present some of the prevailing understanding of the underlying mechanisms and physiology of proteinuria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.