Evidence map›Paper›PMID 21782035›Full record

ReviewJournal of biomedical informatics2011

A review of causal inference for biomedical informatics.

Samantha Kleinberg, George Hripcsak

Abstract readReview
In one paragraph

Review in Journal of biomedical informatics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Characterizing treatment pathways at scale using the OHDSI network.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Pooled it
  2. Article
  3. Article
  4. Article
  5. Evaluating Large Language Models in Extracting Cognitive Exam Dates and Scores.medRxiv : the preprint server for health sciences · 2024
    Article
  6. Article
  7. Article
  8. Assessing the effect ofDialogues in health · 2022
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Frequent Causal Pattern Mining: A Computationally Efficient Framework For Estimating Bias-Corrected Effects.Proceedings : ... IEEE International Conference on Big Data. IEEE International Conference on Big Data · 2019
    Article
  17. Article
  18. Observational
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Samantha KleinbergDepartment of Biomedical Informatics, Columbia University, New York, NY 10032, United States. samantha@dbmi.columbia.edu
George Hripcsak

Funding

DISCOVERING AND APPLYING KNOWLEDGE IN CLINICAL DATABASESR01LM006910 · NLM · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HRIPCSAK, GEORGE M · 2000 to 2023
$10.6M
NLM NIH HHS HHSN276201000024CNLM NIH HHS R01 LM006910
6 · The paper itself

Abstract

Causality is an important concept throughout the health sciences and is particularly vital for informatics work such as finding adverse drug events or risk factors for disease using electronic health records. While philosophers and scientists working for centuries on formalizing what makes something a cause have not reached a consensus, new methods for inference show that we can make progress in this area in many practical cases. This article reviews core concepts in understanding and identifying causality and then reviews current computational methods for inference and explanation, focusing on inference from large-scale observational data. While the problem is not fully solved, we show that graphical models and Granger causality provide useful frameworks for inference and that a more recent approach based on temporal logic addresses some of the limitations of these methods.

Indexed as

CausalityBayes TheoremDrug-Related Side Effects and Adverse ReactionsElectronic Health RecordsEpidemiologyHumansMedical InformaticsPrecision MedicineRisk Factors

Identifiers

PMID21782035
PMCPMC3219814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.