ReviewJournal of molecular and cellular cardiology2011
PET imaging of cardiac hypoxia: opportunities and challenges.
Review in Journal of molecular and cellular cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection.Basic research in cardiology · 2018Guideline
- Disability in mitochondrial aerobic metabolism and MgBMC medicine · 2025Article
- Article
- Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2-NMR in biomedicine · 2024Article
- Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets.Signal transduction and targeted therapy · 2023Review
- Probing Human Heart TCA Cycle Metabolism and Response to Glucose Load using Hyperpolarized [2-medRxiv : the preprint server for health sciences · 2023Article
- Cardiac macrophages and emerging roles for their metabolism after myocardial infarction.The Journal of clinical investigation · 2023Review
- Functionalized Ultrasmall Iron Oxide Nanoparticles forMolecules (Basel, Switzerland) · 2022Article
- The cellular basis of increased PET hypoxia tracer uptake in focal cerebral ischemia with comparison between [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Tissue acidosis does not mediate the hypoxia selectivity of [Scientific reports · 2019Article
- Reperfusion Microvascular Ischemia After Prolonged Coronary Occlusion: Implications And Treatment With Local Supersaturated Oxygen Delivery.Hypoxia (Auckland, N.Z.) · 2019Article
- PET Imaging of Cardiac Hypoxia: Hitting Hypoxia Where It Hurts.Current cardiovascular imaging reports · 2018Review
- Oxygen Sensing, Hypoxia Tracing andFrontiers in chemistry · 2018Review
- Renal Hypoxia in CKD; Pathophysiology and Detecting Methods.Frontiers in physiology · 2017Review
- Imaging of hypoxia in mouse atherosclerotic plaques with (64)Cu-ATSM.Nuclear medicine and biology · 2016Article
- Opportunities and challenges for metal chemistry in molecular imaging: from gamma camera imaging to PET and multimodality imaging.Advances in inorganic chemistry · 2016Article
- Modification of intracellular glutathione status does not change the cardiac trapping of (64)Cu(ATSM).EJNMMI research · 2014Article
- Cardiac hypoxia imaging: second-generation analogues of 64Cu-ATSM.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014Article
- A new method to detect rapid oxygen changes around cells: how quickly do calcium channels sense oxygen in cardiomyocytes?Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Assessing radiotracer kinetics in the Langendorff perfused heart.EJNMMI research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Myocardial hypoxia is a major factor in the pathology of cardiac ischemia and myocardial infarction. Hypoxia also occurs in microvascular disease and cardiac hypertrophy, and is thought to be a prime determinant of the progression to heart failure, as well as the driving force for compensatory angiogenesis. The non-invasive delineation and quantification of hypoxia in cardiac tissue therefore has the potential to be an invaluable experimental, diagnostic and prognostic biomarker for applications in cardiology. However, at this time there are no validated methodologies sufficiently sensitive or reliable for clinical use. PET imaging provides real-time spatial information on the biodistribution of injected radiolabeled tracer molecules. Its inherent high sensitivity allows quantitative imaging of these tracers, even when injected at sub-pharmacological (≥pM) concentrations, allowing the non-invasive investigation of biological systems without perturbing them. PET is therefore an attractive approach for the delineation and quantification of cardiac hypoxia and ischemia. In this review we discuss the key concepts which must be considered when imaging hypoxia in the heart. We summarize the PET tracers which are currently available, and we look forward to the next generation of hypoxia-specific PET imaging agents currently being developed. We describe their potential advantages and shortcomings compared to existing imaging approaches, and what is needed in terms of validation and characterization before these agents can be exploited clinically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.