ArticleBMC neurology2011
Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population.
Article in BMC neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Association between the DRD2 TaqIA gene polymorphism and Parkinson disease risk: an updated meta-analysis.Medicine · 2019Pooled it
- Meta-Analysis of the Effects of the Catechol-O-Methyltransferase Val158/108Met Polymorphism on Parkinson's Disease Susceptibility and Cognitive Dysfunction.Frontiers in genetics · 2019Pooled it
- Val158Met polymorphism of COMT gene and Parkinson's disease risk in Asians.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2015Pooled it
- The relationship between monoamine oxidase B (MAOB) A644G polymorphism and Parkinson disease risk: a meta-analysis.Annals of Saudi medicinePooled it
- Review
- Type A monoamine oxidase; its unique role in mood, behavior and neurodegeneration.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- The Role of Single Nucleotide Polymorphisms of Monoamine Oxidase B, Dopamine D2 Receptor, and DOPA Decarboxylase Receptors Among Patients Treated for Parkinson's Disease.Journal of molecular neuroscience : MN · 2022Article
- Environmental Impact on the Epigenetic Mechanisms Underlying Parkinson's Disease Pathogenesis: A Narrative Review.Brain sciences · 2022Review
- Article
- Polymorphisms of Dopamine Receptor Genes and Parkinson's Disease: Clinical Relevance and Future Perspectives.International journal of molecular sciences · 2021Review
- The Gene Polymorphism of VMAT2 Is Associated with Risk of Schizophrenia in Male Han Chinese.Psychiatry investigation · 2020Article
- Monoamine oxidase B rs1799836 G allele polymorphism is a risk factor for early development of levodopa-induced dyskinesia in Parkinson's disease.eNeurologicalSci · 2020Article
- Gene polymorphisms and motor levodopa-induced complications in Parkinson's disease.Brain and behavior · 2020Article
- Association between dopamine receptor D2 TaqIA polymorphism and Parkinson disease risk: a meta-analysis.International journal of clinical and experimental pathology · 2019Review
- Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism.Clinical oral investigations · 2018Article
- Efficient and biologically relevant consensus strategy for Parkinson's disease gene prioritization.BMC medical genomics · 2016Article
- Comparative analysis of four disease prediction models of Parkinson's disease.Molecular and cellular biochemistry · 2016Article
- Dopaminergic Modulation of Medial Prefrontal Cortex Deactivation in Parkinson Depression.Parkinson's disease · 2015Article
- Article
- Sexual dimorphism in xenobiotic genetic variants-mediated risk for Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2014Article
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Authors and funding
18 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is characterized by alterations in dopaminergic neurotransmission. Genetic polymorphisms involved in dopaminergic neurotransmission may influence susceptibility to PD.
methodsWe investigated the relationship of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), dopamine receptor (DR) D2 and DRD4 polymorphisms and PD risk with special attention to the interaction with cigarette smoking among 238 patients with PD and 369 controls in a Japanese population.
resultsSubjects with the AA genotype of MAOB rs1799836 showed a significantly increased risk of PD (odds ratio (OR) = 1.70, 95% confidence interval (CI) = 1.12 - 2.58) compared with the AG and GG genotypes combined. The AA genotype of COMT rs4680 was marginally associated with an increased risk of PD (OR = 1.86, 95% CI = 0.98 - 3.50) compared with the GG genotype. The DRD2 rs1800497 and DRD4 rs1800955 polymorphisms showed no association with PD. A COMT -smoking interaction was suggested, with the combined GA and AA genotypes of rs4680 and non-smoking conferring significantly higher risk (OR = 3.97, 95% CI = 2.13 - 7.41) than the AA genotype and a history of smoking (P for interaction = 0.061). No interactions of smoking with other polymorphisms were observed.
conclusionsThe COMT rs4680 and MAOB rs1799836 polymorphisms may increase susceptibility to PD risk among Japanese. Future studies involving larger control and case populations and better pesticide exposure histories will undoubtedly lead to a more thorough understanding of the role of the polymorphisms involved in the dopamine pathway in PD.
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