Evidence map›Paper›PMID 21781251›Full record

ReviewJournal of thrombosis and haemostasis : JTH2011

Nanoscale studies of protein-membrane interactions in blood clotting.

J H Morrissey, E Tajkhorshid, C M Rienstra

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of thrombosis and haemostasis : JTH, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Perspectives on Multiscale Colloid-Based Materials for Biomedical Applications.Langmuir : the ACS journal of surfaces and colloids · 2023
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Lipid specificity of the membrane binding domain of coagulation factor X.Journal of thrombosis and haemostasis : JTH · 2017
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. New players in haemostasis and thrombosis.Thrombosis and haemostasis · 2014
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Regulation of tissue factor coagulant activity on cell surfaces.Journal of thrombosis and haemostasis : JTH · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

J H MorrisseyDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. jhmorris@illinois.edu
E Tajkhorshid
C M Rienstra
University of Illinois Urbana-Champaign · USInstitute of Molecular Biology and Biophysics · RU

Funding

WHOLE CELL SIMULATIONP41RR005969 · NCRR · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI STONE, JOHN H · 1990 to 2011
$19.8M
MECHANISMS OF TISSUE FACTOR/FACTOR VII ASSEMBLYR01HL047014 · NHLBI · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI MORRISSEY, JAMES H. · 1992 to 2016
$4.9M
System-Level Simulation of a Bioenergetic MembraneR01GM067887 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2003 to 2018
$4.0M
Structure and Function of Protein-Membrane Interactions in Blood ClottingR01HL103999 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI MORRISSEY, JAMES H., RIENSTRA, CHAD M · 2010 to 2014
$2.8M
Integrated Theoretical and Experimental Studies of P450 Structure and FunctionR01GM079530 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SCHULER, MARY A · 2007 to 2010
$2.1M
High-Field, Wide-Bore Solid-State NMR Spectrometer for Membrane Protein StructureS10RR025037 · NCRR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RIENSTRA, CHAD M · 2008 to 2008
$1.9M
Molecular Mechanisms of Active Transport Across Cellular MembranesR01GM086749 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2009 to 2013
$1.5M
Structure and Function of Membrane Protein Complexes(RMI)R01GM075937 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI RIENSTRA, CHAD M · 2005 to 2009
$1.4M
NCRR NIH HHS P41 RR005969NCRR NIH HHS P41 RR-05969NCRR NIH HHS RR025037NCRR NIH HHS S10 RR025037NHLBI NIH HHS HL103999NHLBI NIH HHS HL47014NHLBI NIH HHS R01 HL047014NHLBI NIH HHS R01 HL103999NIGMS NIH HHS GM75937NIGMS NIH HHS GM79530NIGMS NIH HHS R01 GM067887NIGMS NIH HHS R01-GM067887NIGMS NIH HHS R01 GM075937NIGMS NIH HHS R01 GM079530NIGMS NIH HHS R01 GM086749
6 · The paper itself

Abstract

Most of the steps in the blood clotting cascade require clotting proteins to bind to membrane surfaces with exposed phosphatidylserine. In spite of the importance of these protein-membrane interactions, we still lack a detailed understanding of how clotting proteins interact with membranes and how membranes contribute so profoundly to catalysis. Our laboratories are using multidisciplinary approaches to explore, at atomic-resolution, how blood clotting protein complexes assemble and function on membrane surfaces.

Indexed as

Blood CoagulationNanotechnologyCell MembraneHumansMagnetic Resonance SpectroscopyModels, MolecularMolecular Dynamics SimulationProteinsProteins

Identifiers

PMID21781251
PMCPMC3151027
OpenAlexW1590613780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.