ReviewJournal of thrombosis and haemostasis : JTH2011
Regulating thrombus growth and stability to achieve an optimal response to injury.
Review in Journal of thrombosis and haemostasis : JTH, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 77 citations in OpenAlex.
- Observer variability of absolute and relative thrombus density measurements in patients with acute ischemic stroke.Neuroradiology · 2016Trial
- Dicer Neosynthesis Regulates Platelet Reactivity: A Mechanism Altered in Type 2 Diabetes.Circulation research · 2025Article
- Modulating the platelet-mediated innate foreign body response to affect in situ vascular tissue engineering outcomes.NPJ Regenerative medicine · 2025Article
- Review
- Effect of mechanical thrombectomy with and without intravenous thrombolysis on the functional outcome of patients with different degrees of thrombus perviousness.Neuroradiology · 2023Article
- Occult blood flow patterns distal to an occluded artery in acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Observational
- Article
- Identification of a homozygous recessive variant inHaematologica · 2021Article
- Core and shell platelets of a thrombus: A new microfluidic assay to study mechanics and biochemistry.Research and practice in thrombosis and haemostasis · 2020Article
- A density-dependent FEM-FCT algorithm with application to modeling platelet aggregation.International journal for numerical methods in biomedical engineering · 2019Article
- Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors.Haematologica · 2019Article
- Microclot array elastometry for integrated measurement of thrombus formation and clot biomechanics under fluid shear.Nature communications · 2019Article
- Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model.Regenerative medicine · 2019Article
- Thrombus Permeability on Dynamic CTA Predicts Good Outcome after Reperfusion Therapy.AJNR. American journal of neuroradiology · 2018Article
- Potentiation of thrombus instability: a contributory mechanism to the effectiveness of antithrombotic medications.Journal of thrombosis and thrombolysis · 2018Review
- Article
- Article
- Deposition of fibrinogen on the surface of in vitro thrombi prevents platelet adhesion.Thrombosis research · 2015Article
- Platelet geometry sensing spatially regulates α-granule secretion to enable matrix self-deposition.Blood · 2015Article
- Platelet Rho GTPases-a focus on novel players, roles and relationships.The Biochemical journal · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
An optimal platelet response to injury can be defined as one in which blood loss is restrained and haemostasis is achieved without the penalty of further tissue damage caused by unwarranted vascular occlusion. This brief review considers some of the ways in which thrombus growth and stability can be regulated so that an optimal platelet response can be achieved in vivo. Three related topics are considered. The first focuses on intracellular mechanisms that regulate the early events of platelet activation downstream of G protein coupled receptors for agonists such as thrombin, thromboxane A(2) and ADP. The second considers the ways in which signalling events that are dependent on stable contacts between platelets can influence the state of platelet activation and thus affect thrombus growth and stability. The third focuses on the changes that are experienced by platelets as they move from their normal environment in freely-flowing plasma to a very different environment within the growing haemostatic plug, an environment in which the narrowing gaps and junctions between platelets not only facilitate communication, but also increasingly limit both the penetration of plasma and the exodus of platelet-derived bioactive molecules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.