ArticleThe journal of physical chemistry. B2011
2D-ELDOR study of heterogeneity and domain structure changes in plasma membrane vesicles upon cross-linking of receptors.
Article in The journal of physical chemistry. B, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Axially Chiral Bifluorenylidene Radical Anions with Long Spin-Lattice Relaxation Times at Room Temperature in Fluid Solution.Journal of the American Chemical Society · 2026Article
- Microsecond dynamics in proteins by two-dimensional ESR. II. Addressing computational challenges.The Journal of chemical physics · 2021Article
- Microsecond Exchange Processes Studied by Two-Dimensional ESR at 95 GHz.Journal of the American Chemical Society · 2020Article
- Local ordering and dynamics in anisotropic media by magnetic resonance: from liquid crystals to proteins.Liquid crystals · 2020Article
- Direct Prediction of EPR Spectra from Lipid Bilayers: Understanding Structure and Dynamics in Biological Membranes.Chemphyschem : a European journal of chemical physics and physical chemistry · 2018Article
- Focus: Two-dimensional electron-electron double resonance and molecular motions: The challenge of higher frequencies.The Journal of chemical physics · 2015Article
- DAC-board based X-band EPR spectrometer with arbitrary waveform control.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
2D electron-electron double resonance (2D-ELDOR) with the "full Sc-" method of analysis is applied to the study of plasma membrane vesicles. Membrane structural changes upon antigen cross-linking of IgE receptors (IgE-FcεRI) in plasma membrane vesicles (PMVs) isolated from RBL-2H3 mast cells are investigated, for the first time, by means of these 2D-ELDOR techniques. Spectra of 1-palmitoyl-2-(16-doxyl stearoyl) phosphatidylcholine (16-PC) from PMVs before and after this stimulation at several temperatures are reported. The results demonstrate a coexistence of liquid-ordered (L(o)) and liquid-disordered (L(d)) components. We find that upon cross-linking, the membrane environment is remodeled to become more disordered, as shown by a moderate increase in the population of the L(d) component. This change in the relative amount of the L(o) versus L(d) components upon cross-linking is consistent with a model wherein the IgE receptors, which when clustered by antigen to cause cell stimulation, lead to more disordered lipids, and their dynamic and structural properties are slightly altered. This study demonstrates that 2D-ELDOR, analyzed by the full Sc- method, is a powerful approach for capturing the molecular dynamics in biological membranes. This is a particular case showing how 2D-ELDOR can be applied to study physical processes in complex systems that yield subtle changes.
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Registered trials
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