ArticleJournal of the American Chemical Society2011
Computational design of a β-peptide that targets transmembrane helices.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 57 citations in OpenAlex.
- Single-molecule tweezers decode hidden dimerization patterns of membrane proteins within lipid bilayers.Nature communications · 2025Article
- Computational approaches for the design of modulators targeting protein-protein interactions.Expert opinion on drug discovery · 2023Review
- Spiers Memorial Lecture: Analysis andFaraday discussions · 2021Article
- Insight Into Pathological Integrin αIIbβ3 Activation From Safeguarding The Inactive State.Journal of molecular biology · 2021Article
- Computational Modeling as a Tool to Investigate PPI: From Drug Design to Tissue Engineering.Frontiers in molecular biosciences · 2021Review
- Membrane receptor activation mechanisms and transmembrane peptide tools to elucidate them.The Journal of biological chemistry · 2020Review
- Targeting trimeric transmembrane domain 5 of oncogenic latent membrane protein 1 using a computationally designed peptide.Chemical science · 2019Article
- Article
- Catalytic peptide assemblies.Chemical Society reviews · 2018Review
- Comparing side chain packing in soluble proteins, protein-protein interfaces, and transmembrane proteins.Proteins · 2018Article
- Article
- Drugging Membrane Protein Interactions.Annual review of biomedical engineering · 2016Review
- Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Functional characterization of a melittin analog containing a non-natural tryptophan analog.Biopolymers · 2015Article
- Protein design: Past, present, and future.Biopolymers · 2015Review
- Positive allostery in metal ion binding by a cooperatively folded β-peptide bundle.Journal of the American Chemical Society · 2014Article
- New insights into the interdependence between amino acid stereochemistry and protein structure.Biophysical journal · 2013Article
- Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4.The Journal of biological chemistry · 2013Article
- Strategies to control the binding mode of de novo designed protein interactions.Current opinion in structural biology · 2013Review
- α-Helix mimicry with α/β-peptides.Methods in enzymology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
The design of β-peptide foldamers targeting the transmembrane (TM) domains of complex natural membrane proteins has been a formidable challenge. A series of β-peptides was designed to stably insert in TM orientations in phospholipid bilayers. Their secondary structures and orientation in the phospholipid bilayer was characterized using biophysical methods. Computational methods were then devised to design a β-peptide that targeted a TM helix of the integrin α(IIb)β(3). The designed peptide (β-CHAMP) interacts with the isolated target TM domain of the protein and activates the intact integrin in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.