ArticleEuropean eating disorders review : the journal of the Eating Disorders Association
Association of candidate genes with phenotypic traits relevant to anorexia nervosa.
Article in European eating disorders review : the journal of the Eating Disorders Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Higher-Order Inputs Involved in Appetite Control.Biological psychiatry · 2022Review
- Fear and food: Anxiety-like behavior and the susceptibility to weight loss in an activity-based anorexia rat model.Clinical and translational science · 2022Article
- Development of an AmpliSeqFrontiers in pharmacology · 2018Article
- BDNF-Val66Met variant and adolescent stress interact to promote susceptibility to anorexic behavior in mice.Translational psychiatry · 2016Article
- Contemporary views on the genetics of anorexia nervosa.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2016Review
- Genetic neuropathology of obsessive psychiatric syndromes.Translational psychiatry · 2014Article
- Evidence for the role of EPHX2 gene variants in anorexia nervosa.Molecular psychiatry · 2014Article
- Puberty as a critical risk period for eating disorders: a review of human and animal studies.Hormones and behavior · 2013Review
- Lifetime obesity in patients with eating disorders: increasing prevalence, clinical and personality correlates.European eating disorders review : the journal of the Eating Disorders Association · 2012Article
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Authors and funding
28 authors at 20 institutions in 6 countries.
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Abstract
This analysis is a follow-up to an earlier investigation of 182 genes selected as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN). As those initial case-control results revealed no statistically significant differences in single nucleotide polymorphisms, herein, we investigate alternative phenotypes associated with AN. In 1762 females, using regression analyses, we examined the following: (i) lowest illness-related attained body mass index; (ii) age at menarche; (iii) drive for thinness; (iv) body dissatisfaction; (v) trait anxiety; (vi) concern over mistakes; and (vii) the anticipatory worry and pessimism versus uninhibited optimism subscale of the harm avoidance scale. After controlling for multiple comparisons, no statistically significant results emerged. Although results must be viewed in the context of limitations of statistical power, the approach illustrates a means of potentially identifying genetic variants conferring susceptibility to AN because less complex phenotypes associated with AN are more proximal to the genotype and may be influenced by fewer genes.
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Registered trials
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