ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2011
Regulation of early Xenopus development by the PIAS genes.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Identification and Allelic Variants Associated With Cold Tolerance ofFrontiers in physiology · 2021Article
- A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease.PLoS genetics · 2020Article
- TBX1 is required for normal stria vascularis and semicircular canal development.Developmental biology · 2020Article
- The conserved ancient role of chordate PIAS as a multilevel repressor of the NF-κB pathway.Scientific reports · 2017Article
- PIAS4 is associated with macro/microcephaly in the novel interstitial 19p13.3 microdeletion/microduplication syndrome.European journal of human genetics : EJHG · 2015Article
- Small ubiquitin-like modifier (SUMO)-mediated repression of the Xenopus Oocyte 5 S rRNA genes.The Journal of biological chemistry · 2014Article
- SUMO rules: regulatory concepts and their implication in neurologic functions.Neuromolecular medicine · 2013Review
- Regulation of early xenopus embryogenesis by Smad ubiquitination regulatory factor 2.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Originally identified as cytokine inhibitors, protein inhibitors of activated STAT (PIAS) are shown to regulate activities of a plethora of proteins and influence diverse processes such as immune response, cancer formation, and cell cycle progression. However, the roles of PIAS during vertebrate embryogenesis are less understood. In this study, we report isolation and initial characterization of all four PIAS genes from Xenopus laevis. The Xenopus PIAS genes are expressed throughout early development and have overlapping and distinct expression patterns, with, for example, high levels of PIAS2 in the notochord and strong expression of PIAS4 in the neural and neural crest derivatives. Overexpression of PIAS disrupts mesoderm induction and impairs body axis formation. PIAS proteins have differential ability to regulate signals from the growth factors activin, bone morphogenetic protein 4 (BMP4), and Wnt8. Our data suggest that Xenopus PIAS play important roles in mesodermal induction and patterning during early frog development.
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