ArticleBritish journal of pharmacology1990
Evidence that an atypical beta-adrenoceptor mediates the inhibition of spontaneous rhythmical contractions of rabbit isolated jejunum induced by ritodrine and salbutamol.
Article in British journal of pharmacology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 23 citations in OpenAlex.
- Trial
- Beta-adrenoceptor subtypes mediating the airways response to BRL 35135 in man.British journal of clinical pharmacology · 1993Trial
- Inhibitory effects of SR 58611A on canine colonic motility: evidence for a role of beta 3-adrenoceptors.British journal of pharmacology · 1995Article
- Atypical beta-adrenoceptors in the rat isolated common carotid artery.British journal of pharmacology · 1994Article
- Evaluation of ICI D7114, a putative stimulant of brown adipocytes, on histamine-contracted guinea-pig ileum.British journal of pharmacology · 1993Article
- Characterization of propranolol-resistant (-)-[125I]-cyanopindolol binding sites in rat soleus muscle.British journal of pharmacology · 1993Article
- Effect of BRL-35135 on LTB4-induced guinea pig eosinophil chemotaxis.Agents and actions · 1992Article
- Characterization of catecholamine-mediated relaxations in rat isolated gastric fundus: evidence for an atypical beta-adrenoceptor.British journal of pharmacology · 1991Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The nature of the adrenoceptors mediating the inhibitory action of noradrenaline, ritodrine and salbutamol on the spontaneous activity of longitudinal muscle of the rabbit jejunum in vitro was investigated by use of a range of adrenoceptor antagonists. 2. The actions of ritodrine and salbutamol were antagonized competitively by propranolol. The pA2 values of 6.4 and 6.6 respectively were smaller than those found elsewhere for beta 1- and beta 2-adrenoceptors. 3. In contrast, the responses to ritodrine and salbutamol were antagonized only by high concentrations (greater than 2.7 microM) of phentolamine and were unaffected by yohimbine (2.6 microM), mepyramine (2.5 microM) or cimetidine (4.0 microM). 4. Ritodrine which is less potent than salbutamol in tissues with typical beta 2-adrenoceptors was found to be 8 times more potent than salbutamol in the rabbit jejunum. 5. It is suggested that in the rabbit jejunum ritodrine and salbutamol may act at an atypical beta-adrenoceptor, at which propranolol is a competitive but not very potent antagonist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.