ReviewClinical research in cardiology : official journal of the German Cardiac Society2011
Biomarkers: optimizing treatment guidance in heart failure.
Review in Clinical research in cardiology : official journal of the German Cardiac Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 54 citations in OpenAlex.
- Beneficial effects of renal sympathetic denervation on cardiovascular inflammation and remodeling in essential hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2015Trial
- Impact of Exercise on Physiological, Biochemical, and Analytical Parameters in Patients with Heart Failure with Reduced Ejection Fraction.Medicina (Kaunas, Lithuania) · 2024Review
- Galectin-3 and soluble RAGE as new biomarkers of post-infarction cardiac remodeling.Journal of molecular medicine (Berlin, Germany) · 2021Observational
- Implications of the ACC/AHA risk score for prediction of heart failure: the Rotterdam Study.BMC medicine · 2021Article
- Significance of Atrial and Brain Natriuretic Peptide Measurements in Fetuses With Heart Failure.Frontiers in physiology · 2021Review
- Comparison of clinical efficacy of metoprolol combined with irbesartan and hydrochlorothiazide and non-invasive ventilator in the emergency treatment of patients with severe heart failure.Experimental and therapeutic medicine · 2018Article
- Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Galectin 3: association to neurohumoral activity, echocardiographic parameters and renal function in outpatients with heart failure.BMC cardiovascular disorders · 2016Article
- Labeling galectin-3 for the assessment of myocardial infarction in rats.EJNMMI research · 2014Article
- To ascertain the utility of urinary methyl malonic Acid as a potential marker of ischemic heart failure.Journal of clinical and diagnostic research : JCDR · 2014Article
- Clinical use of novel biomarkers in heart failure: towards personalized medicine.Heart failure reviews · 2014Review
- Connective tissue growth factor (CTGF/CCN2): diagnostic and prognostic value in acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- B-type natriuretic peptide: distribution in the general population and the association with major cardiovascular and coronary events--the Heinz Nixdorf Recall Study.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Article
- Trends in laboratory test volumes for Medicare Part B reimbursements, 2000-2010.Archives of pathology & laboratory medicine · 2014Article
- A modified approach to induce predictable congestive heart failure by volume overload in rats.PloS one · 2014Article
- Angiographic score assessment improves cardiovascular risk prediction: the clinical value of SYNTAX and Gensini application.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Atrial standstill in a patient with progressive severe heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Prognostic value of NT-pro-BNP and hs-CRP for risk stratification in primary care: results from the population-based DETECT study.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
- Assessment of a multimarker strategy for prediction of mortality in older heart failure patients: a cohort study.BMJ open · 2013Article
- Galectin-3 is an independent marker for ventricular remodeling and mortality in patients with chronic heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2013Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart failure is a frequent and life-threatening syndrome which is not only the result of myocardial injury or hemodynamic overload as commonly perceived, but appears to be the result of an interplay among genetic, neurohormonal, inflammatory, and biochemical factors, collectively referred to as biomarkers. Biomarkers can become risk factors in case their therapeutic modification results in an improvement of clinical outcomes. Among those markers identified in patients with heart failure, a number appears to have direct clinical relevance in aiding diagnosis, risk stratification, monitoring therapy, and treating to targets in order to improve clinical outcomes. These include brain natriuretic peptides (e.g., BNP, NT-proBNP), inflammatory markers (e.g., hsCRP), neurohormones (e.g., aldosterone), cardiorenal markers (e.g., cycstatin C), and novel markers (e.g., galectin-3). While their utility to indicate risk is mostly well established, there are less data to establish that a treatment using biomarkers as a guidance results in better outcomes than a more generalized intensified treatment of patients with heart failure. Future directions may involve larger platforms that facilitate to simultaneously analyze hundreds of biomarkers and may help to tailor heart failure therapy on a single patient basis, considering the specific pathogenesis and prognosis. Also from a therapeutic perspective there are data that a single intervention such as aldosterone blockade may affect multiple biomarkers at the same time. Taken together the data indicate that biomarkers are evolving into a valuable addendum to the diagnostic and therapeutic armamentarium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.