ArticleGenes & cancer2011
Regulation of Fertility by the p53 Family Members.
Article in Genes & cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Relation between proteome characterization and semen quality in Italian chicken breeds.PloS one · 2025Article
- Association of rs1570360 and rs2010963 in VEGF and rs2279744 in the MDM2 gene with Recurrent Implantation Failure in Iranian Women.JBRA assisted reproduction · 2023Article
- The Role ofCells · 2023Review
- p63 expression in granulosa-luteinized cells of infertile patients with peritoneal endometriosis submitted to in vitro fertilization.JBRA assisted reproduction · 2022Article
- Utilization of Rosmarinic and Ascorbic Acids for Maturation Culture Media in Order to Increase Sow Oocyte Quality Prior to IVF.Molecules (Basel, Switzerland) · 2021Article
- Hypoxia-Induced miR-378a-3p Inhibits Osteosarcoma Invasion and Epithelial-to-Mesenchymal TransitionFrontiers in genetics · 2021Article
- Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.Cell death and differentiation · 2019Article
- APR-246 reactivates mutant p53 by targeting cysteines 124 and 277.Cell death & disease · 2018Article
- p53 genes function to restrain mobile elements.Genes & development · 2016Article
- The Relationship between Vascular Endothelial Growth Factor 1154G/A Polymorphism and Recurrent Implantation Failure.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015Article
- Np9, a cellular protein of retroviral ancestry restricted to human, chimpanzee and gorilla, binds and regulates ubiquitin ligase MDM2.Cell cycle (Georgetown, Tex.) · 2015Article
- Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis.Endocrine reviews · 2013Review
- Polymorphisms in the p63 and p73 genes are associated with ovarian cancer risk and clinicopathological variables.Journal of experimental & clinical cancer research : CR · 2012Article
- The Regulation of Multiple p53 Stress Responses is Mediated through MDM2.Genes & cancer · 2012Article
- Introduction: The Changing Directions of p53 Research.Genes & cancer · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The p53 family members, which consist of 3 transcription factors-p53, p63, and p73-are conserved during evolution. The p53 family proteins are involved in many important cellular functions, including tumor suppression (p53 and p73), the development of epithelial cell layers (p63), and the development of central nervous system and immune system (p73). Studies on p53-like proteins in low organisms have demonstrated that their primordial functions are to maintain the genomic integrity of germ cells and ensure faithful development and reproduction. In vertebrates, the p53 family proteins retain these functions in reproduction and at the same time have developed additional important functions in reproduction, such as the regulation of embryonic implantation (p53). p53 regulates embryonic implantation through transcriptional regulation of leukemia inhibitory factor (LIF). p63, in particular TAp63, is a main regulator to protect the fidelity of female germ cells during meiotic arrest. p73, in particular TAp73, regulates the ovary function and the quality of oocytes. Loss of p53, p63, or p73 genes in female mice leads to a significant decrease in fertility. These functions of the p53 family proteins in reproduction provide a plausible explanation for positive evolutionary selection observed in a group of single nucleotide polymorphisms and haplotypes in the p53 family genes. A better understanding of the functions of the p53 family proteins in reproduction may lead to new strategies for fertility treatment.
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