ArticlePloS one2011
Neural dynamics during anoxia and the "wave of death".
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
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- Reconstructing rodent brain signals during euthanasia with eigensystem realization algorithm (ERA).Scientific reports · 2024Article
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- Uncertainty quantification and sensitivity analysis of neuron models with ion concentration dynamics.PloS one · 2024Article
- Mechanisms underlying pathological cortical bursts during metabolic depletion.Nature communications · 2023Article
- Preservation of thalamocortical circuitry is essential for good recovery after cardiac arrest.PNAS nexus · 2023Article
- Between life and death: the brain twilight zones.Frontiers in neuroscience · 2023Review
- A review of methods used to kill laboratory rodents: issues and opportunities.Laboratory animals · 2022Review
- An electrodiffusive neuron-extracellular-glia model for exploring the genesis of slow potentials in the brain.PLoS computational biology · 2021Article
- Ion dynamics at the energy-deprived tripartite synapse.PLoS computational biology · 2021Article
- Activity-mediated accumulation of potassium induces a switch in firing pattern and neuronal excitability type.PLoS computational biology · 2021Article
- Spectrum Degradation of Hippocampal LFP During Euthanasia.Frontiers in systems neuroscience · 2021Article
- Diamond nanopillar arrays for quantum microscopy of neuronal signals.Neurophotonics · 2020Article
- An electrodiffusive, ion conserving Pinsky-Rinzel model with homeostatic mechanisms.PLoS computational biology · 2020Article
- A mathematical model of recurrent spreading depolarizations.Journal of computational neuroscience · 2018Article
- The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent experiments in rats have shown the occurrence of a high amplitude slow brain wave in the EEG approximately 1 minute after decapitation, with a duration of 5-15 s (van Rijn et al, PLoS One 6, e16514, 2011) that was presumed to signify the death of brain neurons. We present a computational model of a single neuron and its intra- and extracellular ion concentrations, which shows the physiological mechanism for this observation. The wave is caused by membrane potential oscillations, that occur after the cessation of activity of the sodium-potassium pumps has lead to an excess of extracellular potassium. These oscillations can be described by the Hodgkin-Huxley equations for the sodium and potassium channels, and result in a sudden change in mean membrane voltage. In combination with a high-pass filter, this sudden depolarization leads to a wave in the EEG. We discuss that this process is not necessarily irreversible.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.